Reactome | p-S990,Ac-K1249-BRIP1 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

p-S990,Ac-K1249-BRIP1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9702093] Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9709609] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9980022] ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] - Homo sapiens [Complex:R-HSA-5686616] ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] - Homo sapiens [Complex:R-HSA-5684883] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment - Homo sapiens
created	[InstanceEdit:5687731] Orlic-Milacic, Marija, 2015-04-08
dbId	5687710
displayName	p-S990,Ac-K1249-BRIP1 [nucleoplasm]
endCoordinate	1249
hasModifiedResidue	[ModifiedResidue:5687707] O-phospho-L-serine at 990 [ModifiedResidue:5687708] N6-acetyl-L-lysine at 1249
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-5687710] phospho-p-S990,Ac-K1249-BRIP1 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-5687710] phospho-Brip1 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-5687710] phospho-BRIP1 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-5687710] phospho-BRIP1 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-5687710] phospho-BRIP1 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-5687710] phospho-brip1 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-5687710] phospho-brip1 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-5687710] phospho-p-S990,Ac-K1249-BRIP1 [nucleoplasm] - Gallus gallus [GenomeEncodedEntity:R-DME-5687710] Ghost homologue of p-S990,Ac-K1249-BRIP1 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DDI-5687710] phospho-BRIP1 [nucleoplasm] - Dictyostelium discoideum
maxDepth	1
name	p-S990,Ac-K1249-BRIP1 p-S990,Ac-K1249-FANCJ p-S990,Ac-K1249-BACH1
producedByEvent	[BlackBoxEvent:R-HSA-5686483] Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) - Homo sapiens [Reaction:R-HSA-5686410] BLM mediates dissolution of double Holliday junction - Homo sapiens [Reaction:R-HSA-5693589] D-loop dissociation and strand annealing - Homo sapiens [BlackBoxEvent:R-HSA-5686663] Completion of SSA - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q9BX63] UniProt:Q9BX63 BRIP1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-5687710
startCoordinate	1

Referrals

(hasComponent)	[Complex:R-HSA-9702093] Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] [Complex:R-HSA-9709609] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1 [nucleoplasm] [Complex:R-HSA-9980022] ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Complex:R-HSA-5686616] ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Complex:R-HSA-5685989] 3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] [Complex:R-HSA-5686226] Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Complex:R-HSA-5686487] Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Complex:R-HSA-5685658] D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Complex:R-HSA-5686227] Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Complex:R-HSA-5686428] Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Complex:R-HSA-5684883] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] [Complex:R-HSA-5685317] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] [Complex:R-HSA-5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Complex:R-HSA-5684128] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(output)	[BlackBoxEvent:R-HSA-5686663] Completion of SSA [Reaction:R-HSA-5686410] BLM mediates dissolution of double Holliday junction [BlackBoxEvent:R-HSA-5686483] Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [Reaction:R-HSA-5693589] D-loop dissociation and strand annealing
(input)	[Reaction:R-HSA-5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment

© 2026 Reactome

Cite Us!