Reactome | TBK1, IKBKE phosphorylate RIPK1 at T189

Schema > Reaction > Entries

TBK1, IKBKE phosphorylate RIPK1 at T189 Show undefined attributes

catalystActivity	[CatalystActivity:10323597] protein serine/threonine kinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10323599
displayName	TBK1, IKBKE phosphorylate RIPK1 at T189
eventOf	[Pathway:R-CFA-5357905] Regulation of TNFR1 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9817397] TBK1, IKBKE phosphorylate RIPK1 at T189 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TBK1, IKBKE phosphorylate RIPK1 at T189
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-9817389] TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9817397
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5357905] Regulation of TNFR1 signaling
(inferredTo)	[Reaction:R-HSA-9817397] TBK1, IKBKE phosphorylate RIPK1 at T189