Reactome | CYLD:SPATA2:LUBAC [cytosol]

Schema > Complex > Entries

CYLD:SPATA2:LUBAC [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CFA-9796343] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] - Canis familiaris [Complex:R-CFA-9817389] TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Canis familiaris [Complex:R-CFA-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Canis familiaris [Complex:R-CFA-9818791] TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10232896
displayName	CYLD:SPATA2:LUBAC [cytosol]
hasComponent	2 × [EntityWithAccessionedSequence:R-CFA-741420] CYLD [cytosol] 2 × [Complex:R-CFA-5357865] LUBAC [cytosol] 2 × [EntityWithAccessionedSequence:R-CFA-9796351] SPATA2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9796690] CYLD:SPATA2:LUBAC [cytosol] - Homo sapiens
maxDepth	3
name	CYLD:SPATA2:LUBAC
producedByEvent	[Reaction:R-CFA-9796691] SPATA2 links CYLD to LUBAC - Canis familiaris [BlackBoxEvent:R-CFA-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex - Canis familiaris [BlackBoxEvent:R-CFA-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-9796690
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-CFA-9818791] TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] [Complex:R-CFA-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] [Complex:R-CFA-9796343] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] [Complex:R-CFA-9817363] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] [Complex:R-CFA-9817389] TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
(output)	[BlackBoxEvent:R-CFA-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex [BlackBoxEvent:R-CFA-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex [Reaction:R-CFA-9796691] SPATA2 links CYLD to LUBAC
(input)	[Reaction:R-CFA-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex
(inferredTo)	[Complex:R-HSA-9796690] CYLD:SPATA2:LUBAC [cytosol]

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