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CYLD:SPATA2:LUBAC [cytosol]
Stable Identifier
R-CFA-9796690
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
TNFR1-induced proapoptotic signaling (Canis familiaris)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
CYLD [cytosol]
(Canis familiaris)
x 2
LUBAC [cytosol]
(Canis familiaris)
x 2
SPATA2 [cytosol]
(Canis familiaris)
Participates
as a component of
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
as an output of
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
as an input of
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
Inferred From
CYLD:SPATA2:LUBAC [cytosol]
(Homo sapiens)
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