Reactome | TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10323637
displayName	TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane]
hasComponent	[CandidateSet:R-CFA-5357900] BIRC2,3,4 [cytosol] [Complex:R-CFA-9796690] CYLD:SPATA2:LUBAC [cytosol] [Complex:R-CFA-177663] IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] [EntityWithAccessionedSequence:R-CFA-9818793] phospho-RIPK1 [cytosol] [DefinedSet:R-CFA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-CFA-66376] TRADD [cytosol] 3 × [EntityWithAccessionedSequence:R-CFA-66370] TRAF2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9818791] TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] - Homo sapiens
maxDepth	5
name	TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG
producedByEvent	[Reaction:R-CFA-9818789] CHUK, IKBKB phosphorylate RIPK1 at S25 - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-9818791
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-CFA-9818789] CHUK, IKBKB phosphorylate RIPK1 at S25
(inferredTo)	[Complex:R-HSA-9818791] TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane]

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