Reactome | LUBAC ubiquitinates RIPK1 at K627

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LUBAC ubiquitinates RIPK1 at K627 Show undefined attributes

catalystActivity	[CatalystActivity:10323305] ubiquitin-protein transferase activity of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10323307
displayName	LUBAC ubiquitinates RIPK1 at K627
eventOf	[Pathway:R-CFA-5357905] Regulation of TNFR1 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - Canis familiaris
inferredFrom	[BlackBoxEvent:R-HSA-9793679] LUBAC ubiquitinates RIPK1 at K627 - Homo sapiens
input	[Complex:R-CFA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] [Complex:R-CFA-8938763] Ub:UBE2L3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LUBAC ubiquitinates RIPK1 at K627
output	[Complex:R-CFA-9793688] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] [EntityWithAccessionedSequence:R-CFA-8864201] UBE2L3 [cytosol]
precedingEvent	[Reaction:R-CFA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-9793679
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5357905] Regulation of TNFR1 signaling
(precedingEvent)	[Reaction:R-CFA-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex
(inferredTo)	[BlackBoxEvent:R-HSA-9793679] LUBAC ubiquitinates RIPK1 at K627