Reactome | TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10287691
displayName	TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane]
hasComponent	[CandidateSet:R-CFA-5357900] BIRC2,3,4 [cytosol] [Complex:R-CFA-5357865] LUBAC [cytosol] [EntityWithAccessionedSequence:R-CFA-9793681] RIPK1 [cytosol] [DefinedSet:R-CFA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-CFA-66376] TRADD [cytosol] 3 × [EntityWithAccessionedSequence:R-CFA-66370] TRAF2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9793688] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] - Homo sapiens
maxDepth	5
memberOf	[DefinedSet:R-CFA-9793686] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] - Canis familiaris
name	TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC
positivelyRegulates	[PositiveRegulation:10287704] Positive regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane]'
producedByEvent	[BlackBoxEvent:R-CFA-9793679] LUBAC ubiquitinates RIPK1 at K627 - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-9793688
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(regulator)	[PositiveRegulation:10287704] Positive regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane]'
(output)	[BlackBoxEvent:R-CFA-9793679] LUBAC ubiquitinates RIPK1 at K627
(hasMember)	[DefinedSet:R-CFA-9793686] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane]
(inferredTo)	[Complex:R-HSA-9793688] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane]

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