Reactome | Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)

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Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329351
displayName	Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
eventOf	[Pathway:R-CFA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221070] TRIF-dependent toll-like receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-2201338] TRAF3 binds TICAM1:activated TLR4 complex - Canis familiaris [BlackBoxEvent:R-CFA-2213017] Auto-ubiquitination of TRAF3 - Canis familiaris [Reaction:R-CFA-5362486] TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 - Canis familiaris [BlackBoxEvent:R-CFA-5362500] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Canis familiaris [Reaction:R-CFA-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Canis familiaris [Reaction:R-CFA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Canis familiaris [Reaction:R-CFA-9823910] Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Canis familiaris [Reaction:R-CFA-9823906] TBK1 is phosphorylated within the activated TLR4 complex - Canis familiaris [Reaction:R-CFA-166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 - Canis familiaris [Reaction:R-CFA-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Canis familiaris [Reaction:R-CFA-168933] Dimerization of phosphorylated IRF3/IRF7 - Canis familiaris [Reaction:R-CFA-177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus - Canis familiaris [Pathway:R-CFA-9824878] Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7 - Canis familiaris
inferredFrom	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-936964
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-937061] TRIF (TICAM1)-mediated TLR4 signaling
(inferredTo)	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)

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