Reactome | Purine catabolism

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Purine catabolism Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328819
displayName	Purine catabolism
eventOf	[Pathway:R-CFA-8956319] Nucleotide catabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:16129] purine nucleotide catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-109278] NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP - Canis familiaris [Reaction:R-CFA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Canis familiaris [Reaction:R-CFA-109415] AMP + H2O => adenosine + orthophosphate [NT5C1B] - Canis familiaris [Reaction:R-CFA-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Canis familiaris [Reaction:R-CFA-109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - Canis familiaris [Reaction:R-CFA-8953339] DNPH1 hydrolyses dGMP - Canis familiaris [Reaction:R-CFA-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose - Canis familiaris [Reaction:R-CFA-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Canis familiaris [Reaction:R-CFA-74255] Guanine + H2O => Xanthine + NH4+ - Canis familiaris [Reaction:R-CFA-74247] XDH oxidizes hypoxanthine to form xanthine - Canis familiaris [Reaction:R-CFA-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Canis familiaris [Reaction:R-CFA-74258] XDH oxidizes xanthine to form urate - Canis familiaris [Reaction:R-CFA-9727349] XDH dehydrogenates xanthine to form urate - Canis familiaris [Pathway:R-CFA-2393930] Phosphate bond hydrolysis by NUDT proteins - Canis familiaris [Reaction:R-CFA-2509827] ITPA hydrolyses ITP to IMP - Canis familiaris [Reaction:R-CFA-2509831] ITPA hydrolyses XTP to XMP - Canis familiaris [Reaction:R-CFA-2509838] ITPA hydrolyses dITP to dIMP - Canis familiaris
inferredFrom	[Pathway:R-HSA-74259] Purine catabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Purine catabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-74259
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8956319] Nucleotide catabolism
(inferredTo)	[Pathway:R-HSA-74259] Purine catabolism

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