Reactome | PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose

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PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose Show undefined attributes

catalystActivity	[CatalystActivity:10230866] purine-nucleoside phosphorylase activity of PNP trimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10230888
displayName	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose
eventOf	[Pathway:R-CFA-74259] Purine catabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-74255] Guanine + H2O => Xanthine + NH4+ - Canis familiaris
inferredFrom	[Reaction:R-HSA-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose - Homo sapiens
input	[DefinedSet:R-ALL-500245] G, dG [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine 2'-deoxyguanosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + guanine
output	[SimpleEntity:R-ALL-83956] Gua [cytosol] [DefinedSet:R-ALL-500244] R1P, dRibP [cytosol]
precedingEvent	[Reaction:R-CFA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-74249
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-74259] Purine catabolism
(precedingEvent)	[Reaction:R-CFA-74255] Guanine + H2O => Xanthine + NH4+
(inferredTo)	[Reaction:R-HSA-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose

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