Reactome | ITPA hydrolyses ITP to IMP

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ITPA hydrolyses ITP to IMP Show undefined attributes

catalystActivity	[CatalystActivity:10279973] ITP diphosphatase activity of ITPA dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10279975
displayName	ITPA hydrolyses ITP to IMP
eventOf	[Pathway:R-CFA-74259] Purine catabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2509827] ITPA hydrolyses ITP to IMP - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-2509836] ITP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ITPA hydrolyses ITP to IMP ITP + H2O => IMP + diphosphate + H(+)
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29602] IMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
regulatedBy	[Requirement:R-HSA-389378] Requirement by 'Mg2+ [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2509827
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-74259] Purine catabolism
(inferredTo)	[Reaction:R-HSA-2509827] ITPA hydrolyses ITP to IMP

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