Reactome | Ub [nucleoplasm]

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Ub [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-CFA-5655177] MonoUb:K15,K24-KIAA0101 [nucleoplasm] - Canis familiaris [Complex:R-CFA-8864169] Ub:E2 (UBA1 substrate) [nucleoplasm] - Canis familiaris [Complex:R-CFA-6781851] Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Canis familiaris [Reaction:R-CFA-6804879] MDM2 ubiquitinates TP53 - Canis familiaris [Reaction:R-CFA-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Canis familiaris [Reaction:R-CFA-3322429] XIAP monoubiquinates TLE - Canis familiaris [Reaction:R-CFA-6804942] MDM2 homodimers auto-ubiquitinate - Canis familiaris [Reaction:R-CFA-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Canis familiaris [BlackBoxEvent:R-CFA-5655193] KIAA0101 double monoubiquitination - Canis familiaris [Reaction:R-CFA-5655170] RCHY1 monoubiquitinates POLH - Canis familiaris [Reaction:R-CFA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Canis familiaris [Reaction:R-CFA-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 - Canis familiaris [Reaction:R-CFA-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 - Canis familiaris [Reaction:R-CFA-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Canis familiaris [Reaction:R-CFA-8952419] SMURFs ubiquitinate RUNX3 - Canis familiaris [Reaction:R-CFA-8952382] MDM2 polyubiquitinates RUNX3 - Canis familiaris [Reaction:R-CFA-6804253] MDM2 ubiquitinates JMY - Canis familiaris [Reaction:R-CFA-6782943] UV-DDB ubiquitinates XPC - Canis familiaris [Reaction:R-CFA-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Canis familiaris [Reaction:R-CFA-2179276] SMURF2 monoubiquitinates SMAD3 - Canis familiaris [Reaction:R-CFA-870449] TRIM33 monoubiquitinates SMAD4 - Canis familiaris [Reaction:R-CFA-1363331] Ubiquitination of p130 (RBL2) by SCF (Skp2) - Canis familiaris [Reaction:R-CFA-187575] Ubiquitination of phospho-p27/p21 - Canis familiaris [Reaction:R-CFA-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Canis familiaris [Reaction:R-CFA-174057] Multiubiquitination of APC/C-associated Cdh1 - Canis familiaris [BlackBoxEvent:R-CFA-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 - Canis familiaris [Reaction:R-CFA-2176502] NEDD4L ubiquitinates SMAD2/3 - Canis familiaris [Reaction:R-CFA-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 - Canis familiaris [Reaction:R-CFA-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin - Canis familiaris [Reaction:R-CFA-6798373] MDM2 ubiquitinates DYRK2 - Canis familiaris [Reaction:R-CFA-6804441] RNF34 or RFFL ubiquitinates phosphorylated TP53 - Canis familiaris [Reaction:R-CFA-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Canis familiaris [Reaction:R-CFA-8852128] UBA1 adenylates ubiquitin in the nucleoplasm - Canis familiaris
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10098911
displayName	Ub [nucleoplasm]
hasMember	[EntityWithAccessionedSequence:R-CFA-939849] RPS27A [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-CFA-939844] UBA52 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-CFA-939847] UBB [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-CFA-939871] UBC [nucleoplasm] - Canis familiaris
inDisease	false
inferredFrom	[DefinedSet:R-HSA-68524] Ub [nucleoplasm] - Homo sapiens
name	Ub Ubiquitin UBIQ_HUMAN
producedByEvent	[Reaction:R-CFA-5655466] USP1:WDR48 deubiquitinates monoUb:K164-PCNA - Canis familiaris [BlackBoxEvent:R-CFA-8939801] 26S proteasome degrades PolyUb-RUNX2 - Canis familiaris [Reaction:R-CFA-6786171] FANCD2 deubiquitination by USP1:WDR48 - Canis familiaris [BlackBoxEvent:R-CFA-188191] APC/C:Cdh1-mediated degradation of Skp2 - Canis familiaris [BlackBoxEvent:R-CFA-68825] Ubiquitinated geminin is degraded by the proteasome - Canis familiaris [Reaction:R-CFA-3215295] USP7 deubiquitinates MDM2 - Canis familiaris [Reaction:R-CFA-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Canis familiaris [Reaction:R-CFA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Canis familiaris [Reaction:R-CFA-5690157] USP16,USP21 deubiquitinate Histone H2A - Canis familiaris [Reaction:R-CFA-5690080] USP3,SAGA deubiquitinate Histone H2A,H2B - Canis familiaris [Reaction:R-CFA-5696960] USP49 deubiquitinates H2B - Canis familiaris [Reaction:R-CFA-5691381] MYSM1 deubiquitinates Histone H2A - Canis familiaris [Reaction:R-CFA-5690790] Histone H2A is dubiquitinated by the PR-DUB complex - Canis familiaris [Reaction:R-CFA-5653770] USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA - Canis familiaris [BlackBoxEvent:R-CFA-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Canis familiaris [BlackBoxEvent:R-CFA-5635854] GLI2,3 are degraded by the proteasome - Canis familiaris [BlackBoxEvent:R-CFA-174058] Degradation of multiubiquitinated Cdh1 - Canis familiaris [Reaction:R-CFA-6807118] USP7 deubiquitinates monoubiquitinated PTEN - Canis familiaris [BlackBoxEvent:R-CFA-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - Canis familiaris
schemaClass	DefinedSet
species	[Species:49646] Canis familiaris
stId	R-CFA-68524

Referrals

(hasComponent)	[Complex:R-CFA-8864169] Ub:E2 (UBA1 substrate) [nucleoplasm] [Complex:R-CFA-8852095] Ub-Cys632-UBA1 [nucleoplasm] [Complex:R-CFA-8942129] Ub:UBE2A,B [nucleoplasm] [Complex:R-CFA-8943019] Ub:UBE2N [nucleoplasm] [Complex:R-CFA-5655177] MonoUb:K15,K24-KIAA0101 [nucleoplasm] [Complex:R-CFA-5655156] MonoUb:K682,K686,K694,K709-POLH [nucleoplasm] [Complex:R-CFA-420751] MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] [Complex:R-CFA-420750] MonoUb:K523,p-4S-FANCI [nucleoplasm] [Complex:R-CFA-6782951] Ub:XPC [nucleoplasm] [Complex:R-CFA-6790516] Ub,SUMO,K63polyUb:XPC [nucleoplasm] [Complex:R-CFA-6790462] Ub,SUMO:XPC [nucleoplasm] [Complex:R-CFA-5651984] MonoUb:K164-PCNA [nucleoplasm] [Complex:R-CFA-187568] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] [Complex:R-CFA-2186733] Ub-SKI/Ub-SKIL [nucleoplasm] [Complex:R-CFA-2186778] Ub-SMAD7 [nucleoplasm] [Complex:R-CFA-1363324] Ub-p-T401,S672,1035-RBL2 [nucleoplasm] [Complex:R-CFA-174068] multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] [Complex:R-CFA-2176504] Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] [Complex:R-CFA-3788734] Ub-EHMT1 [nucleoplasm] [Complex:R-CFA-3788727] Ub-EHMT2 [nucleoplasm] [Complex:R-CFA-205097] K63 linked polyubiquitin chain [nucleoplasm] [Complex:R-CFA-1234123] UBE2D1,2,3:Ubiquitin [nucleoplasm] [Complex:R-CFA-1234100] ub-hydroxyPro-HIF-alpha [nucleoplasm] [Complex:R-CFA-6781851] Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] [Complex:R-CFA-6781849] Ub:ERCC6 [nucleoplasm] [Complex:R-CFA-5696466] Ub:ERCC1 [nucleoplasm]
(input)	[Reaction:R-CFA-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus [Reaction:R-CFA-8852128] UBA1 adenylates ubiquitin in the nucleoplasm [BlackBoxEvent:R-CFA-5655193] KIAA0101 double monoubiquitination [Reaction:R-CFA-5655170] RCHY1 monoubiquitinates POLH [Reaction:R-CFA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA [Reaction:R-CFA-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 [Reaction:R-CFA-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 [Reaction:R-CFA-8939706] SCF(SKP2) polyubiquitinates RUNX2 [Reaction:R-CFA-8952419] SMURFs ubiquitinate RUNX3 [Reaction:R-CFA-8952382] MDM2 polyubiquitinates RUNX3 [Reaction:R-CFA-6804253] MDM2 ubiquitinates JMY [Reaction:R-CFA-6782943] UV-DDB ubiquitinates XPC [Reaction:R-CFA-5682858] RNF8 and RNF168 ubiquitinate H2AFX [Reaction:R-CFA-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B [Reaction:R-CFA-2179276] SMURF2 monoubiquitinates SMAD3 [Reaction:R-CFA-870449] TRIM33 monoubiquitinates SMAD4 [Reaction:R-CFA-1363331] Ubiquitination of p130 (RBL2) by SCF (Skp2) [Reaction:R-CFA-187575] Ubiquitination of phospho-p27/p21 [Reaction:R-CFA-9686969] APC/C:Cdh1 polyubiquitinates SKP2 [Reaction:R-CFA-174057] Multiubiquitination of APC/C-associated Cdh1 [Reaction:R-CFA-6804879] MDM2 ubiquitinates TP53 [BlackBoxEvent:R-CFA-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 [Reaction:R-CFA-2176502] NEDD4L ubiquitinates SMAD2/3 [Reaction:R-CFA-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 [Reaction:R-CFA-6804724] MDM2 ubiquitinates phosphorylated MDM4 [Reaction:R-CFA-3322429] XIAP monoubiquinates TLE [Reaction:R-CFA-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin [Reaction:R-CFA-6798373] MDM2 ubiquitinates DYRK2 [Reaction:R-CFA-6804942] MDM2 homodimers auto-ubiquitinate [Reaction:R-CFA-6804441] RNF34 or RFFL ubiquitinates phosphorylated TP53 [Reaction:R-CFA-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
(output)	[Reaction:R-CFA-5690157] USP16,USP21 deubiquitinate Histone H2A [Reaction:R-CFA-5690080] USP3,SAGA deubiquitinate Histone H2A,H2B [Reaction:R-CFA-5696960] USP49 deubiquitinates H2B [Reaction:R-CFA-5691381] MYSM1 deubiquitinates Histone H2A [Reaction:R-CFA-5690790] Histone H2A is dubiquitinated by the PR-DUB complex [Reaction:R-CFA-5655466] USP1:WDR48 deubiquitinates monoUb:K164-PCNA [Reaction:R-CFA-5653770] USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA [BlackBoxEvent:R-CFA-9762096] Ub,pS335,S338,T NFE2L2 is degraded [BlackBoxEvent:R-CFA-5635854] GLI2,3 are degraded by the proteasome [BlackBoxEvent:R-CFA-8939801] 26S proteasome degrades PolyUb-RUNX2 [Reaction:R-CFA-6786171] FANCD2 deubiquitination by USP1:WDR48 [BlackBoxEvent:R-CFA-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome [BlackBoxEvent:R-CFA-174058] Degradation of multiubiquitinated Cdh1 [BlackBoxEvent:R-CFA-188191] APC/C:Cdh1-mediated degradation of Skp2 [BlackBoxEvent:R-CFA-68825] Ubiquitinated geminin is degraded by the proteasome [Reaction:R-CFA-6807118] USP7 deubiquitinates monoubiquitinated PTEN [Reaction:R-CFA-3215295] USP7 deubiquitinates MDM2 [Reaction:R-CFA-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 [Reaction:R-CFA-6782069] UVSSA:USP7 deubiquitinates ERCC6
(inferredTo)	[DefinedSet:R-HSA-68524] Ub [nucleoplasm]

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