Reactome | Interleukin-6 family signaling

Schema > Pathway > Entries

compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330433
displayName	Interleukin-6 family signaling
eventOf	[Pathway:R-CFA-449147] Signaling by Interleukins - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8651] cytokine-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-CFA-1059683] Interleukin-6 signaling - Canis familiaris [Pathway:R-CFA-6788467] IL-6-type cytokine receptor ligand interactions - Canis familiaris
inferredFrom	[Pathway:R-HSA-6783589] Interleukin-6 family signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Interleukin-6 family signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-6783589
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-449147] Signaling by Interleukins
(hasEncapsulatedEvent)	[Pathway:R-CFA-2559582] Senescence-Associated Secretory Phenotype (SASP) [Pathway:R-CFA-9958825] Activation of STAT3 by cadherin engagement
(inferredTo)	[Pathway:R-HSA-6783589] Interleukin-6 family signaling

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