Reactome | DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10320582] cysteine-type endopeptidase activity of TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-CFA-9697750] RIPK1 is cleaved by CASP8:FLIP(L) - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10283315
displayName	DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-CFA-3465408] CASP8 [cytosol] [EntityWithAccessionedSequence:R-CFA-3465404] CASP8 [cytosol] [Complex:R-CFA-140977] TRADD:TRAF2:RIPK1:FADD [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9697746] TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] - Homo sapiens [Complex:R-HSA-3465431] DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] - Homo sapiens
maxDepth	4
name	DISC:p43/p41CASP8:p43 FLIP(L)
producedByEvent	[BlackBoxEvent:R-CFA-3465448] Caspase-8 and FLIP(L) processing at DISC - Canis familiaris [BlackBoxEvent:R-CFA-9697747] Caspase-8 and FLIP(L) processing at TNFR signaling complex - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-3465431
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[BlackBoxEvent:R-CFA-9697750] RIPK1 is cleaved by CASP8:FLIP(L)
(physicalEntity)	[CatalystActivity:10320582] cysteine-type endopeptidase activity of TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane]
(output)	[BlackBoxEvent:R-CFA-9697747] Caspase-8 and FLIP(L) processing at TNFR signaling complex [BlackBoxEvent:R-CFA-3465448] Caspase-8 and FLIP(L) processing at DISC
(inferredTo)	[Complex:R-HSA-9697746] TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] [Complex:R-HSA-3465431] DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane]