Reactome | Phosphorylation and activation of VAV2/VAV3 by SYK

Schema > Reaction > Entries

Phosphorylation and activation of VAV2/VAV3 by SYK Show undefined attributes

catalystActivity	[CatalystActivity:10278912] protein tyrosine kinase activity of DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10279283
displayName	Phosphorylation and activation of VAV2/VAV3 by SYK
eventOf	[Pathway:R-CFA-2424491] DAP12 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-2424476] Activation of RAC1 by VAV2/3 - Canis familiaris
inferredFrom	[Reaction:R-HSA-2424486] Phosphorylation and activation of VAV2/VAV3 by SYK - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-2424461] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation and activation of VAV2/VAV3 by SYK
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-2424469] p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane]
precedingEvent	[Reaction:R-CFA-2424481] Recruitment of VAV and BTK to p-SLP-76 - Canis familiaris [Reaction:R-CFA-2395412] Phosphorylation of SYK - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2424486
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2424491] DAP12 signaling
(precedingEvent)	[Reaction:R-CFA-2424476] Activation of RAC1 by VAV2/3
(inferredTo)	[Reaction:R-HSA-2424486] Phosphorylation and activation of VAV2/VAV3 by SYK

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