Reactome | Phosphorylation of SYK

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Phosphorylation of SYK Show undefined attributes

catalystActivity	[CatalystActivity:10278880] protein tyrosine kinase activity of DAP12 receptors:p-DAP12:SYK [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10278882
displayName	Phosphorylation of SYK
eventOf	[Pathway:R-CFA-2424491] DAP12 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-2424482] p85 regulatory unit of PI3K binds p-6Y-SYK - Canis familiaris [Reaction:R-CFA-2395801] Phosphorylation of LAT by p-SYK - Canis familiaris [Reaction:R-CFA-2424486] Phosphorylation and activation of VAV2/VAV3 by SYK - Canis familiaris [Reaction:R-CFA-2424487] Phosphorylation of PLC-gamma by p-BTK/p-SYK - Canis familiaris [Reaction:R-CFA-2424484] Phosphorylation of BTK by p-SYK - Canis familiaris [Reaction:R-CFA-2396594] Phosphorylation of SLP-76 by p-SYK - Canis familiaris
inferredFrom	[Reaction:R-HSA-2395412] Phosphorylation of SYK - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-210250] DAP12 receptors:p-DAP12:SYK [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of SYK
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-2395411] DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane]
precedingEvent	[Reaction:R-CFA-210289] Recruitment of SYK to p-DAP12 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2395412
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2424491] DAP12 signaling
(precedingEvent)	[Reaction:R-CFA-2424486] Phosphorylation and activation of VAV2/VAV3 by SYK [Reaction:R-CFA-2424487] Phosphorylation of PLC-gamma by p-BTK/p-SYK [Reaction:R-CFA-2424484] Phosphorylation of BTK by p-SYK [Reaction:R-CFA-2424482] p85 regulatory unit of PI3K binds p-6Y-SYK [Reaction:R-CFA-2396594] Phosphorylation of SLP-76 by p-SYK [Reaction:R-CFA-2395801] Phosphorylation of LAT by p-SYK
(inferredTo)	[Reaction:R-HSA-2395412] Phosphorylation of SYK