Reactome | Recruitment of VAV and BTK to p-SLP-76

Schema > Reaction > Entries

Recruitment of VAV and BTK to p-SLP-76 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10153522
displayName	Recruitment of VAV and BTK to p-SLP-76
eventOf	[Pathway:R-CFA-2424491] DAP12 signaling - Canis familiaris
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-2424486] Phosphorylation and activation of VAV2/VAV3 by SYK - Canis familiaris [Reaction:R-CFA-2424484] Phosphorylation of BTK by p-SYK - Canis familiaris
inferredFrom	[Reaction:R-HSA-2424481] Recruitment of VAV and BTK to p-SLP-76 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-197948] BTK [cytosol] [Complex:R-CFA-2424460] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [DefinedSet:R-CFA-2424458] VAV2,VAV3 [cytosol]
isInDisease	false
isInferred	true
name	Recruitment of VAV and BTK to p-SLP-76
output	[Complex:R-CFA-2424461] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-CFA-2396594] Phosphorylation of SLP-76 by p-SYK - Canis familiaris [Reaction:R-CFA-2424480] PI3K phosphorylates PIP2 to PIP3 - Canis familiaris
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2424481
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2424491] DAP12 signaling
(precedingEvent)	[Reaction:R-CFA-2424486] Phosphorylation and activation of VAV2/VAV3 by SYK [Reaction:R-CFA-2424484] Phosphorylation of BTK by p-SYK
(inferredTo)	[Reaction:R-HSA-2424481] Recruitment of VAV and BTK to p-SLP-76