Reactome | Signaling by Hippo

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Signaling by Hippo Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330885
displayName	Signaling by Hippo
eventOf	[TopLevelPathway:R-CFA-162582] Signal Transduction - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:937682] hippo signaling
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Canis familiaris [Reaction:R-CFA-2028284] Phosphorylation of STK4 (MST1) and SAV1 by STK4 - Canis familiaris [Reaction:R-CFA-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Canis familiaris [Reaction:R-CFA-2028692] Cleavage of p-STK4 (p-MST1) by caspase 3 - Canis familiaris [Reaction:R-CFA-2038398] KIBRA (WWC1) binds LATS proteins - Canis familiaris [Reaction:R-CFA-2059926] NPHP4 protein binds LATS proteins - Canis familiaris [Reaction:R-CFA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Canis familiaris [Reaction:R-CFA-2028673] Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N - Canis familiaris [Reaction:R-CFA-2028555] Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) - Canis familiaris [Reaction:R-CFA-2028679] Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N - Canis familiaris [Reaction:R-CFA-2028635] Phosphorylation of MOB1A and B by p-STK3 (p-MST2) - Canis familiaris [Reaction:R-CFA-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Canis familiaris [Reaction:R-CFA-2028629] Phosphorylation of MOB1A and B by p-STK4 (p-MST1) - Canis familiaris [Reaction:R-CFA-2028670] Phosphorylation of MOB1A and B by p-STK4(MST1)/N - Canis familiaris [Reaction:R-CFA-2028626] Phosphorylated MOB1A proteins associate with LATS proteins - Canis familiaris [Reaction:R-CFA-2032770] Translocation of YAP1 to the nucleus - Canis familiaris [Reaction:R-CFA-2064421] YAP1 binds ZO-2 (TJP2) - Canis familiaris [Reaction:R-CFA-2064406] Translocation of YAP1:ZO-2 (TJP2) to the nucleus - Canis familiaris [Reaction:R-CFA-2028724] AMOT proteins bind YAP1 - Canis familiaris [Reaction:R-CFA-2028598] Phosphorylation of YAP by LATS1 - Canis familiaris [Reaction:R-CFA-2028583] Phosphorylation of YAP by LATS2 - Canis familiaris [Reaction:R-CFA-2032768] Translocation of WWTR1 (TAZ) to the nucleus - Canis familiaris [Reaction:R-CFA-2064417] WWTR1 (TAZ) binds ZO-1 (TJP1) - Canis familiaris [Reaction:R-CFA-2064418] WWTR1 (TAZ) binds ZO-2 (TJP2) - Canis familiaris [Reaction:R-CFA-2028735] AMOT proteins bind WWTR1 (TAZ) - Canis familiaris [Reaction:R-CFA-2060328] Phosphorylation of WWTR1 (TAZ) by LATS1 - Canis familiaris [Reaction:R-CFA-2028661] Phosphorylation of WWTR1 (TAZ) by LATS2 - Canis familiaris [Reaction:R-CFA-2066299] DVL2 binds phosphorylated WWTR1 (TAZ) - Canis familiaris [Reaction:R-CFA-2028651] YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) - Canis familiaris
inferredFrom	[Pathway:R-HSA-2028269] Signaling by Hippo - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Signaling by Hippo Hippo signaling cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-2028269
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-CFA-162582] Signal Transduction
(hasEncapsulatedEvent)	[Pathway:R-CFA-1236394] Signaling by ERBB4 [Pathway:R-CFA-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression
(inferredTo)	[Pathway:R-HSA-2028269] Signaling by Hippo

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