Reactome | Cleavage of p-STK4 (p-MST1) by caspase 3

Schema > Reaction > Entries

Cleavage of p-STK4 (p-MST1) by caspase 3 Show undefined attributes

catalystActivity	[CatalystActivity:10244668] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10275364
displayName	Cleavage of p-STK4 (p-MST1) by caspase 3
eventOf	[Pathway:R-CFA-2028269] Signaling by Hippo - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-2028670] Phosphorylation of MOB1A and B by p-STK4(MST1)/N - Canis familiaris [Reaction:R-CFA-2028679] Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N - Canis familiaris
inferredFrom	[Reaction:R-HSA-2028692] Cleavage of p-STK4 (p-MST1) by caspase 3 - Homo sapiens
input	[Complex:R-CFA-2028266] p-STK4:p-SAV1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of p-STK4 (p-MST1) by caspase 3
output	[Complex:R-CFA-2028698] p-STK4/N:p-SAV1 [cytosol] 2 × [EntityWithAccessionedSequence:R-CFA-2028668] STK4 [cytosol]
precedingEvent	[Reaction:R-CFA-2028284] Phosphorylation of STK4 (MST1) and SAV1 by STK4 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2028692
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2028269] Signaling by Hippo
(precedingEvent)	[Reaction:R-CFA-2028679] Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N [Reaction:R-CFA-2028670] Phosphorylation of MOB1A and B by p-STK4(MST1)/N
(inferredTo)	[Reaction:R-HSA-2028692] Cleavage of p-STK4 (p-MST1) by caspase 3

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