Reactome | VAV1 [cytosol]

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VAV1 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CFA-9029096] GRB2-1:VAV1 [cytosol] - Canis familiaris [Complex:R-CFA-389334] VAV1:PIP3:CD28:GRB2 [plasma membrane] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-879914] IL3 stimulation induces Vav binding to Tec kinase - Canis familiaris [Reaction:R-CFA-912727] CBL binds VAV - Canis familiaris [Reaction:R-CFA-1433542] Phosphorylation and activation of VAV1 - Canis familiaris [Reaction:R-CFA-389352] Translocation of Vav1 to CD28 - Canis familiaris [Reaction:R-CFA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10246474
displayName	VAV1 [cytosol]
endCoordinate	845
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-195066] VAV1 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[CandidateSet:R-CFA-442295] VAV family [cytosol] - Canis familiaris [CandidateSet:R-CFA-194849] GEFs [cytosol] - Canis familiaris [CandidateSet:R-CFA-9014432] RHOG GEFs [cytosol] - Canis familiaris [CandidateSet:R-CFA-9014398] RAC2 GEFs [cytosol] - Canis familiaris [CandidateSet:R-CFA-9013168] RAC1 GEFs [cytosol] - Canis familiaris [CandidateSet:R-CFA-8980694] RHOA GEFs [cytosol] - Canis familiaris
name	VAV1 VAV1 A0A8I3NA65
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I3NA65] UniProt:A0A8I3NA65
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-195066
startCoordinate	1

Referrals

(hasComponent)	[Complex:R-CFA-9029096] GRB2-1:VAV1 [cytosol] [Complex:R-CFA-912729] TEC:VAV1 [cytosol] [Complex:R-CFA-912755] p(Y700,731,774)-CBL:VAV1 [cytosol] [Complex:R-CFA-389334] VAV1:PIP3:CD28:GRB2 [plasma membrane] [Complex:R-CFA-9606167] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane]
(hasMember)	[CandidateSet:R-CFA-8980694] RHOA GEFs [cytosol] [CandidateSet:R-CFA-9014398] RAC2 GEFs [cytosol] [CandidateSet:R-CFA-9013168] RAC1 GEFs [cytosol] [CandidateSet:R-CFA-9014432] RHOG GEFs [cytosol] [CandidateSet:R-CFA-194849] GEFs [cytosol] [CandidateSet:R-CFA-442295] VAV family [cytosol] [DefinedSet:R-CFA-430172] VAV1,2,3 [cytosol]
(input)	[Reaction:R-CFA-1433542] Phosphorylation and activation of VAV1 [Reaction:R-CFA-879914] IL3 stimulation induces Vav binding to Tec kinase [Reaction:R-CFA-912727] CBL binds VAV [Reaction:R-CFA-389352] Translocation of Vav1 to CD28 [Reaction:R-CFA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-195066] VAV1 [cytosol]

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