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VAV1 [cytosol]
Stable Identifier
R-CFA-195066
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
VAV1, A0A8I3NA65
Locations in the PathwayBrowser
Expand all
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)
PIP3:VAV1,2,3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
VAV family:PIP2 [plasma membrane] (Canis familiaris)
VAV family [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
p-SLP-76 binds VAV (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
p-SLP-76:VAV [cytosol] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent Vav1 pathway (Canis familiaris)
Activation of Vav1 (Canis familiaris)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Translocation of Vav1 to CD28 (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BTK binds BTK inhibitors (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
BTK:BTK inhibitors [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
IL3 stimulation induces Vav binding to Tec kinase (Canis familiaris)
TEC:VAV1 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Regulation of signaling by CBL (Canis familiaris)
CBL binds VAV (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Autophosphorylation of BTK/ITK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
FCERI mediated MAPK activation (Canis familiaris)
Phosphorylation and activation of VAV (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Recruitment of VAV to p-SLP-76 (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Phosphorylation of VAV (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NRAGE signals death through JNK (Canis familiaris)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Canis familiaris)
GEFs [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates RAS (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Canis familiaris)
GRB2-1:VAV1 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
GRB2-1:VAV1 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (12/13) signalling events (Canis familiaris)
GEFs activate RhoA,B,C (Canis familiaris)
GEFs [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by SCF-KIT (Canis familiaris)
Phosphorylation and activation of VAV1 (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
Src kinases phosphorylate VAV (Canis familiaris)
PIP3:VAV1,2,3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
VAV family [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 GEFs activate RAC1 (Canis familiaris)
RAC1 GEFs [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
RAC2 GTPase cycle (Canis familiaris)
RAC2 GEFs activate RAC2 (Canis familiaris)
RAC2 GEFs [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
RHOA GTPase cycle (Canis familiaris)
RHOA GEFs activate RHOA (Canis familiaris)
RHOA GEFs [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
RHOG GTPase cycle (Canis familiaris)
RHOG GEFs activate RHOG (Canis familiaris)
RHOG GEFs [cytosol] (Canis familiaris)
VAV1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NA65
Gene Names
VAV1
Reference Genes
BioGPS Gene:485016 VAV1
ENSEMBL:ENSCAFG00845008896.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008896.1 VAV1
Monarch:485016 VAV1
NCBI Gene:485016 VAV1
Reference Transcript
RefSeq:XM_542134.5 VAV1
Other Identifiers
485016
CfaAffx.28423.1.S1_s_at
GO:0001784
GO:0002376
GO:0005085
GO:0005515
GO:0005911
GO:0006909
GO:0006955
GO:0007155
GO:0007166
GO:0007186
GO:0007229
GO:0008361
GO:0016192
GO:0023052
GO:0030154
GO:0030217
GO:0030593
GO:0035556
GO:0042110
GO:0045785
GO:0045954
GO:0048856
GO:0048870
GO:0072593
GO:0098542
GO:0098772
GO:0140031
Participates
as a component of
GRB2-1:VAV1 [cytosol] (Canis familiaris)
TEC:VAV1 [cytosol] (Canis familiaris)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Canis familiaris)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
as a member of
RHOA GEFs [cytosol] (Canis familiaris)
RAC2 GEFs [cytosol] (Canis familiaris)
RAC1 GEFs [cytosol] (Canis familiaris)
RHOG GEFs [cytosol] (Canis familiaris)
GEFs [cytosol] (Canis familiaris)
VAV family [cytosol] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
as an input of
Phosphorylation and activation of VAV1 (Canis familiaris)
IL3 stimulation induces Vav binding to Tec kinase (Canis familiaris)
CBL binds VAV (Canis familiaris)
Translocation of Vav1 to CD28 (Canis familiaris)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
Other forms of this molecule
phospho-VAV1 [plasma membrane]
phospho-VAV1 [cytosol]
VAV1 [plasma membrane]
Inferred From
VAV1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_542134.2
OpenTargets
ENSG00000141968
Ensembl
ENSCAFG00845008896
,
ENSCAFP00845012298
,
ENSCAFT00845015810
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