Reactome | IKBKB [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CFA-9861512] p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] - Canis familiaris [Complex:R-CFA-9836494] EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-5609665] CHUK, IKBKB and IKBKG form IKK complex - Canis familiaris [Reaction:R-CFA-9749505] LRRC14 binds IKBKB and CHUK - Canis familiaris [Reaction:R-CFA-9750226] NLRC5 binds IKBKB and CHUK - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10242455
displayName	IKBKB [cytosol]
endCoordinate	756
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-168114] IKBKB [cytosol] - Homo sapiens
maxDepth	1
name	IKBKB IKBKB A0A8I3N4F2
producedByEvent	[BlackBoxEvent:R-CFA-9750946] TRAF2,6 ubiquitinates NLRC5 - Canis familiaris
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I3N4F2] UniProt:A0A8I3N4F2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-168114
startCoordinate	1

(hasComponent)	[Complex:R-CFA-9861512] p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] [Complex:R-CFA-193897] IKBKB dimer [cytosol] [Complex:R-CFA-9836494] EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] [Complex:R-CFA-9749467] CHUK:IKBKB:LRRC14 [cytosol] [Complex:R-CFA-9750228] CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] [Complex:R-CFA-168113] CHUK:IKBKB:IKBKG [cytosol]
(input)	[Reaction:R-CFA-9749505] LRRC14 binds IKBKB and CHUK [Reaction:R-CFA-9750226] NLRC5 binds IKBKB and CHUK [Reaction:R-CFA-5609665] CHUK, IKBKB and IKBKG form IKK complex
(output)	[BlackBoxEvent:R-CFA-9750946] TRAF2,6 ubiquitinates NLRC5
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-168114] IKBKB [cytosol]

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