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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
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Analysis Gene Expression
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Diseases
Cytomics
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Citing us
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Analyse gene expression
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IKBKB [cytosol]
Stable Identifier
R-CFA-168114
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
IKBKB, A0A8I3N4F2
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Activation of IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
PKR-mediated signaling (Canis familiaris)
IKK complex is activated by PKR (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
NEMO binds polyubiquitinated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
Phosphorylation of IKK-beta by TAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
IKK complex recruitment mediated by RIP1 (Canis familiaris)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
GNB2L1 binds IKKA:IKKB:NEMO (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IKKbeta is activated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
IKBKB dimer [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
p75NTR recruits signalling complexes (Canis familiaris)
IKK-beta is recruited (Canis familiaris)
IKBKB dimer [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
IKBKB dimer [cytosol] (Canis familiaris)
IKBKB [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N4F2
Gene Names
IKBKB
Reference Genes
BioGPS Gene:482839 IKBKB
ENSEMBL:ENSCAFG00845006197.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006197.1 IKBKB
Monarch:482839 IKBKB
NCBI Gene:482839 IKBKB
Reference Transcript
RefSeq:XM_014120062.1 IKBKB
RefSeq:XM_539954.5 IKBKB
Other Identifiers
482839
Cfa.8326.1.A1_at
CfaAffx.9249.1.S1_at
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0007010
GO:0007249
GO:0008384
GO:0016740
GO:0019901
GO:0023052
GO:0030154
GO:0030866
GO:0033209
GO:0034330
GO:0036211
GO:0042325
GO:0042802
GO:0042803
GO:0043123
GO:0045944
GO:0046982
GO:0048856
GO:0051604
GO:0070498
GO:0071356
GO:0072659
GO:0097110
GO:0140096
GO:1903140
GO:1903347
GO:1990459
Participates
as a component of
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKB dimer [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
as an input of
LRRC14 binds IKBKB and CHUK (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
as an output of
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
Other forms of this molecule
phospho-IKBKB [cytosol]
Inferred From
IKBKB [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_013975537.1
,
XP_539954.2
OpenTargets
ENSG00000104365
Ensembl
ENSCAFP00845008588
,
ENSCAFT00845011002
,
ENSCAFG00845006197
© 2024
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