Reactome | NLRC5 binds IKBKB and CHUK

Schema > Reaction > Entries

NLRC5 binds IKBKB and CHUK Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10322093
displayName	NLRC5 binds IKBKB and CHUK
eventOf	[Pathway:R-CFA-9758274] Regulation of NF-kappa B signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-9750946] TRAF2,6 ubiquitinates NLRC5 - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:162165] negative regulation of canonical NF-kappaB signal transduction
inferredFrom	[Reaction:R-HSA-9750226] NLRC5 binds IKBKB and CHUK - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-168104] CHUK [cytosol] [EntityWithAccessionedSequence:R-CFA-168114] IKBKB [cytosol] [EntityWithAccessionedSequence:R-CFA-937324] NLRC5 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NLRC5 binds IKBKB and CHUK NLRC5 binds IKBKB and IKBKA
output	[Complex:R-CFA-9750228] CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-CFA-9750942] USP14 deubiquitinates NLRC5 - Canis familiaris
regulatedBy	[NegativeRegulation:10322094] Negative regulation by 'K63polyUb-NLRC5 [cytosol]' [PositiveRegulation:10322095] Positive regulation by 'USP14 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9750226
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9758274] Regulation of NF-kappa B signaling
(precedingEvent)	[BlackBoxEvent:R-CFA-9750946] TRAF2,6 ubiquitinates NLRC5
(inferredTo)	[Reaction:R-HSA-9750226] NLRC5 binds IKBKB and CHUK

Cite Us!