Reactome | TBC1D2A accelerates GTP hydrolysis by RAB7

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TBC1D2A accelerates GTP hydrolysis by RAB7 Show undefined attributes

catalystActivity	[CatalystActivity:10980850] GTPase activity of RAB7A:GTP [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10980857
displayName	TBC1D2A accelerates GTP hydrolysis by RAB7
eventOf	[Pathway:R-CEL-8854214] TBC/RABGAPs - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-CEL-2213222] RAB7A:GTP [lysosomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TBC1D2A accelerates GTP hydrolysis by RAB7 TBC1D2A accerlates GTP hydrolysis by RAB7
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-CEL-8854176] RAB7A:GDP [lysosomal membrane]
regulatedBy	[PositiveRegulation:10980858] Positive regulation by 'TBC1D2 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8854255
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8854214] TBC/RABGAPs
(inferredTo)	[Reaction:R-HSA-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7

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