Reactome | Negative regulation of FLT3

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Negative regulation of FLT3 Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10446158
displayName	Negative regulation of FLT3
eventOf	[Pathway:R-BTA-9607240] FLT3 Signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-9698408] PTPRJ dephosphorylates active FLT3 - Bos taurus [Reaction:R-BTA-9706293] Active FLT3 binds to CBL - Bos taurus [Reaction:R-BTA-9706350] FLT3 phosphorylates CBL - Bos taurus [Reaction:R-BTA-9706328] Active FLT3 binds to SOCS2 - Bos taurus [Reaction:R-BTA-9706330] Active FLT3 binds to SOCS6 - Bos taurus [Reaction:R-BTA-9706319] Active FLT3 binds to SLA - Bos taurus [Reaction:R-BTA-9706323] Active FLT3 binds to SLA2 - Bos taurus [Reaction:R-BTA-9706315] Active FLT3 binds to SH2B3 - Bos taurus [BlackBoxEvent:R-BTA-9706354] Ubiquitination of FLT3 - Bos taurus [BlackBoxEvent:R-BTA-9706364] Internalization of ubiquitinated FLT3 - Bos taurus [Reaction:R-BTA-9706298] Active FLT3 binds to CSK - Bos taurus [Reaction:R-BTA-9706287] Active FLT3 binds to ABL2 - Bos taurus
inferredFrom	[Pathway:R-HSA-9706369] Negative regulation of FLT3 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Negative regulation of FLT3
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-9706369
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9607240] FLT3 Signaling
(inferredTo)	[Pathway:R-HSA-9706369] Negative regulation of FLT3

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