Reactome | PTPRJ dephosphorylates active FLT3

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PTPRJ dephosphorylates active FLT3 Show undefined attributes

catalystActivity	[CatalystActivity:10416712] protein tyrosine phosphatase activity of PTPRJ [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10434408
displayName	PTPRJ dephosphorylates active FLT3
eventOf	[Pathway:R-BTA-9706369] Negative regulation of FLT3 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9698408] PTPRJ dephosphorylates active FLT3 - Homo sapiens
input	[Complex:R-BTA-9604751] Active FLT3 [plasma membrane] 8 × [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTPRJ dephosphorylates active FLT3
output	[Complex:R-BTA-9698407] p-Y768,Y969 FLT3 dimer:FLT3LG dimer [plasma membrane] 8 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:R-BTA-9604767] FLT3LG dimer:FLT3 dimer autophosphorylates - Bos taurus
regulatedBy	[NegativeRegulation:9702479] Negative regulation by 'H2O2 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9698408
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9706369] Negative regulation of FLT3
(inferredTo)	[Reaction:R-HSA-9698408] PTPRJ dephosphorylates active FLT3

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