Reactome | Interferon alpha/beta signaling

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Interferon alpha/beta signaling Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444820
displayName	Interferon alpha/beta signaling
eventOf	[Pathway:R-BTA-913531] Interferon Signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:383670] type I interferon-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-909720] IFN alpha/beta binds to IFNAR2 - Bos taurus [Reaction:R-BTA-9696179] IFNAR2:JAK1:STAT2 binds type 1 interferon analogs - Bos taurus [Reaction:R-BTA-9678935] IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors - Bos taurus [Reaction:R-BTA-909724] Recruitment of IFNAR1 - Bos taurus [Reaction:R-BTA-9678737] IFNAR1:TYK2 binds TYK2 inhibitors - Bos taurus [Reaction:R-BTA-909729] Activation of JAK kinases - Bos taurus [Reaction:R-BTA-909730] Phosphorylation of INFAR1 by TYK2 - Bos taurus [Reaction:R-BTA-909719] Recruitment of STAT2 to p-IFNAR1 - Bos taurus [Reaction:R-BTA-909732] Phosphorylation of STAT2 - Bos taurus [Reaction:R-BTA-909722] Release of p-STAT2:p-STAT1 dimer - Bos taurus [Reaction:R-BTA-909725] Interaction of IRF9 with p-STAT2:p-STAT1 - Bos taurus [Reaction:R-BTA-909718] Formation of p-STAT1 homodimer - Bos taurus [Reaction:R-BTA-9710959] p-STAT1 dimer binds KPNA1 - Bos taurus [Reaction:R-BTA-9710963] p-STAT1dimer:KPNA1 binds KPNB1 - Bos taurus [Reaction:R-BTA-909721] Translocation of ISGF3 complex to nucleus - Bos taurus [Reaction:R-BTA-913529] Translocation of p-STAT1:p-STAT1 dimer to nucleus - Bos taurus [Pathway:R-BTA-912694] Regulation of IFNA/IFNB signaling - Bos taurus [Reaction:R-BTA-5223305] ABCE1 binds RNASEL, inhibiting it - Bos taurus
inferredFrom	[Pathway:R-HSA-909733] Interferon alpha/beta signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Interferon alpha/beta signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-909733
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-913531] Interferon Signaling
(hasEncapsulatedEvent)	[Pathway:R-BTA-9833482] PKR-mediated signaling
(inferredTo)	[Pathway:R-HSA-909733] Interferon alpha/beta signaling

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