Reactome | Regulation of IFNA/IFNB signaling

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Regulation of IFNA/IFNB signaling Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444822
displayName	Regulation of IFNA/IFNB signaling
eventOf	[Pathway:R-BTA-909733] Interferon alpha/beta signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:383408] regulation of type I interferon-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-912685] UBP43 binds IFNAR2 and prevents JAK1 interaction - Bos taurus [Reaction:R-BTA-997311] Dephosphorylation of TYK2 by PTP1B - Bos taurus [Reaction:R-BTA-997314] Dephosphorylation of JAK1 by SHP1 - Bos taurus [Reaction:R-BTA-997309] Dephosphorylation of STAT1 by SHP2 - Bos taurus
inferredFrom	[Pathway:R-HSA-912694] Regulation of IFNA/IFNB signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of IFNA/IFNB signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-912694
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-909733] Interferon alpha/beta signaling
(inferredTo)	[Pathway:R-HSA-912694] Regulation of IFNA/IFNB signaling

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