Reactome | IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10433966
displayName	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors
eventOf	[Pathway:R-BTA-909733] Interferon alpha/beta signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9678935] IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors - Homo sapiens
input	[Complex:R-BTA-918193] IFNAR2:JAK1:STAT2 [plasma membrane] [DefinedSet:R-ALL-9678984] JAK1,2 inhibitors [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors
output	[Complex:R-BTA-9678951] IFNAR2:JAK1:STAT2:JAK1,2 inhibitors [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9678935
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-909733] Interferon alpha/beta signaling
(inferredTo)	[Reaction:R-HSA-9678935] IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors

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