Reactome | Assembly of EGFR complex in clathrin-coated vesicles

Schema > Reaction > Entries

Assembly of EGFR complex in clathrin-coated vesicles Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10347832
displayName	Assembly of EGFR complex in clathrin-coated vesicles
eventOf	[Pathway:R-BTA-182971] EGFR downregulation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Bos taurus [Reaction:R-BTA-183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 - Bos taurus
inferredFrom	[Reaction:R-HSA-182994] Assembly of EGFR complex in clathrin-coated vesicles - Homo sapiens
input	[Complex:R-BTA-8875480] CIN85:endophilin [cytosol] [Complex:R-BTA-182948] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Assembly of EGFR complex in clathrin-coated vesicles
output	[Complex:R-BTA-182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane]
precedingEvent	[Reaction:R-BTA-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-182994
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-182971] EGFR downregulation
(precedingEvent)	[Reaction:R-BTA-8867044] EGFR binds EPS15, EPN1, EPS15L1 [Reaction:R-BTA-183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
(inferredTo)	[Reaction:R-HSA-182994] Assembly of EGFR complex in clathrin-coated vesicles

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