Reactome | HC23,45-HMGB1 [extracellular region]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-BTA-6801223] HC23,45-HMGB1:LTA [extracellular region] - Bos taurus
consumedByEvent	[Reaction:R-BTA-6804099] HMGB1 binds LTP - Bos taurus [Reaction:R-BTA-6804100] HMGB1 binds LPS - Bos taurus [Reaction:R-BTA-5432825] HMGB1 binds TLR4:LY96 - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10400119
displayName	HC23,45-HMGB1 [extracellular region]
endCoordinate	215
hasModifiedResidue	[IntraChainCrosslinkedResidue:10400117] Intra-chain Crosslink via L-cystine (cross-link) at 23 and 45 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-6797422] HC23,45-HMGB1 [extracellular region] - Homo sapiens
maxDepth	1
name	HC23,45-HMGB1 P10103
producedByEvent	[BlackBoxEvent:R-BTA-6805981] HMGB1 release from cells - Bos taurus
referenceEntity	[ReferenceGeneProduct:uniprot:P10103] UniProt:P10103
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-6797422
startCoordinate	2

(input)	[Reaction:R-BTA-6804099] HMGB1 binds LTP [Reaction:R-BTA-6804100] HMGB1 binds LPS [Reaction:R-BTA-5432825] HMGB1 binds TLR4:LY96
(hasComponent)	[Complex:R-BTA-6801223] HC23,45-HMGB1:LTA [extracellular region] [Complex:R-BTA-6801229] HC23,45-HMGB1:LPS [extracellular region] [Complex:R-BTA-5432869] HC23,45-HMGB1:TLR4:LY96 [plasma membrane]
(output)	[BlackBoxEvent:R-BTA-6805981] HMGB1 release from cells
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-6797422] HC23,45-HMGB1 [extracellular region]

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