Reactome | HMGB1 binds TLR4:LY96

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HMGB1 binds TLR4:LY96 Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10400123
displayName	HMGB1 binds TLR4:LY96
eventOf	[Pathway:R-BTA-5686938] Regulation of TLR by endogenous ligand - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5432825] HMGB1 binds TLR4:LY96 - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-6797422] HC23,45-HMGB1 [extracellular region] [Complex:R-BTA-166050] TLR4:LY96 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	HMGB1 binds TLR4:LY96 HMGB1 binds TLR4:MD2
output	[Complex:R-BTA-5432869] HC23,45-HMGB1:TLR4:LY96 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-BTA-6805981] HMGB1 release from cells - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5432825
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5686938] Regulation of TLR by endogenous ligand
(inferredTo)	[Reaction:R-HSA-5432825] HMGB1 binds TLR4:LY96

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