Reactome | HMGB1 binds LPS

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10415981
displayName	HMGB1 binds LPS
eventOf	[Pathway:R-BTA-5686938] Regulation of TLR by endogenous ligand - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6804100] HMGB1 binds LPS - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-6797422] HC23,45-HMGB1 [extracellular region] [SimpleEntity:R-ALL-166005] LPS [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	HMGB1 binds LPS
output	[Complex:R-BTA-6801229] HC23,45-HMGB1:LPS [extracellular region]
precedingEvent	[BlackBoxEvent:R-BTA-6805981] HMGB1 release from cells - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-6804100
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-5686938] Regulation of TLR by endogenous ligand
(inferredTo)	[Reaction:R-HSA-6804100] HMGB1 binds LPS