Reactome | RNF4 ubiquitinates MDC1

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RNF4 ubiquitinates MDC1 Show undefined attributes

catalystActivity	[CatalystActivity:10405721] ubiquitin protein ligase activity of RNF4 homodimer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10405723
displayName	RNF4 ubiquitinates MDC1
eventOf	[Pathway:R-BTA-5693607] Processing of DNA double-strand break ends - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5684081] MRN complex binds CDK2 and RBBP8 - Bos taurus [Reaction:R-BTA-5684108] BRCA1 binds phosphorylated RBBP8 - Bos taurus
inferredFrom	[Reaction:R-HSA-5684071] RNF4 ubiquitinates MDC1 - Homo sapiens
input	[Complex:R-BTA-5684053] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] 6 × [DefinedSet:R-BTA-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RNF4 ubiquitinates MDC1
output	[EntityWithAccessionedSequence:R-BTA-5682582] BABAM1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5682579] BABAM2 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5682577] BRCC3 [nucleoplasm] [Complex:R-BTA-5682162] DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Complex:R-BTA-5684077] K48PolyUb:SUMO2:K1840,p-5T-MDC1 dimer [nucleoplasm] [Complex:R-BTA-5682998] K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] [DefinedSet:R-BTA-9707299] p-5S-BRCA1:p-2T-BARD1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5682575] phospho-ABRAXAS1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5682615] phospho-HERC2 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5682984] phospho-NSD2 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5683418] phospho-TP53BP1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-2993789] PIAS4 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-4551605] RNF168 [nucleoplasm] [Complex:R-BTA-5682540] RNF8:Zn2+ [nucleoplasm] [Complex:R-BTA-5682542] UBE2N:UBE2V2 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5682574] UIMC1 [nucleoplasm]
precedingEvent	[Reaction:R-BTA-5684052] PIAS4 SUMOylates MDC1 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5684071
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-BTA-5684108] BRCA1 binds phosphorylated RBBP8 [Reaction:R-BTA-5684081] MRN complex binds CDK2 and RBBP8
(inferredTo)	[Reaction:R-HSA-5684071] RNF4 ubiquitinates MDC1

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