Reactome | K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-BTA-5682995] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10334006
displayName	K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm]
hasComponent	2 × [GenomeEncodedEntity:R-BTA-5682847] Ghost homologue of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] 2 × [CandidateSet:R-BTA-181911] Histone H2B [nucleoplasm] 2 × [DefinedSet:R-BTA-181914-3] Homologues of HIST3H3 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-BTA-5651652] Me2K21-HIST1H4 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5682998] K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] - Homo sapiens
maxDepth	4
name	K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome
producedByEvent	[Reaction:R-BTA-5684071] RNF4 ubiquitinates MDC1 - Bos taurus [Reaction:R-BTA-5693599] Association of Ku heterodimer with ends of DNA double-strand break - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-5682998
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-BTA-5693599] Association of Ku heterodimer with ends of DNA double-strand break [Reaction:R-BTA-5684071] RNF4 ubiquitinates MDC1
(hasComponent)	[Complex:R-BTA-5682995] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm]
(inferredTo)	[Complex:R-HSA-5682998] K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm]

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