Reactome | phospho-TP53BP1 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-BTA-5684065] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] - Bos taurus [Complex:R-BTA-5683417] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10334054
displayName	phospho-TP53BP1 [nucleoplasm]
endCoordinate	1972
hasModifiedResidue	[ModifiedResidue:10334051] O-phospho-L-serine at 25 (in Homo sapiens) [ModifiedResidue:10334052] O-phospho-L-serine at 1778 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-5683418] p-S25,S1778-TP53BP1 [nucleoplasm] - Homo sapiens
maxDepth	1
name	phospho-TP53BP1 p-S25,S1778-TP53BP1 E1BDS6
producedByEvent	[Reaction:R-BTA-5684071] RNF4 ubiquitinates MDC1 - Bos taurus [Reaction:R-BTA-5693599] Association of Ku heterodimer with ends of DNA double-strand break - Bos taurus
referenceEntity	[ReferenceGeneProduct:uniprot:E1BDS6] UniProt:E1BDS6
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-5683418
startCoordinate	1

(output)	[Reaction:R-BTA-5693599] Association of Ku heterodimer with ends of DNA double-strand break [Reaction:R-BTA-5684071] RNF4 ubiquitinates MDC1
(hasComponent)	[Complex:R-BTA-5684065] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] [Complex:R-BTA-5683417] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-5683418] p-S25,S1778-TP53BP1 [nucleoplasm]