Reactome | TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex

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TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10399342
displayName	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex
eventOf	[Pathway:R-BTA-5357956] TNFR1-induced NF-kappa-B signaling pathway - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex - Homo sapiens
input	[Complex:R-BTA-446878] TAK1 complex [cytosol] [Complex:R-BTA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex
output	[Complex:R-BTA-5357837] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-BTA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Bos taurus [Reaction:R-BTA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Bos taurus
regulatedBy	[NegativeRegulation:10399306] Negative regulation by 'RIPK1 deubiquitinases [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5357860
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5357956] TNFR1-induced NF-kappa-B signaling pathway
(inferredTo)	[Reaction:R-HSA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex

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