Reactome | TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-BTA-5693059] TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] - Bos taurus [Complex:R-BTA-5357950] CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] - Bos taurus
consumedByEvent	[BlackBoxEvent:R-BTA-5357845] K63polyUb-RIPK1 is deubiquitinated - Bos taurus [Reaction:R-BTA-5693055] TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes - Bos taurus [Reaction:R-BTA-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex - Bos taurus [Reaction:R-BTA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Bos taurus [Reaction:R-BTA-5357928] CLIP3 and CYLD bind TNF signaling complex - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10399280
displayName	TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
hasComponent	[CandidateSet:R-BTA-5357900] BIRC2,3,4 [cytosol] [EntityWithAccessionedSequence:R-BTA-937021] RIPK1 [cytosol] [DefinedSet:R-BTA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-BTA-66376] TRADD [cytosol] 3 × [EntityWithAccessionedSequence:R-BTA-66370] TRAF2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] - Homo sapiens
maxDepth	5
name	TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4
producedByEvent	[BlackBoxEvent:R-BTA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-5357756
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-BTA-5357928] CLIP3 and CYLD bind TNF signaling complex [Reaction:R-BTA-5693055] TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes [Reaction:R-BTA-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex [Reaction:R-BTA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC [BlackBoxEvent:R-BTA-5357845] K63polyUb-RIPK1 is deubiquitinated
(hasComponent)	[Complex:R-BTA-5357950] CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] [Complex:R-BTA-5693059] TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] [Complex:R-BTA-9796343] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] [Complex:R-BTA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
(output)	[BlackBoxEvent:R-BTA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1
(inferredTo)	[Complex:R-HSA-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]

TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] Show undefined attributes

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