Reactome | PTPN11 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PTPN11 [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10374396] protein tyrosine phosphatase activity of PTPN11 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-205267] SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] - Bos taurus [Complex:R-BTA-8855762] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] - Bos taurus
consumedByEvent	[Reaction:R-BTA-8987132] IL22:p?Y251,p?Y301?IL22RA1:p?JAK1:PTPN11:IL10RB:p?TYK2 binds PTPN11 - Bos taurus [Reaction:R-BTA-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Bos taurus [Reaction:R-BTA-8865994] GAB1 binds PTPN11 - Bos taurus [Reaction:R-BTA-205238] SHP2 interacts with p-KIT - Bos taurus [Reaction:R-BTA-210294] Interaction of PECAM-1 and SHP-2 - Bos taurus [Reaction:R-BTA-204873] Interaction of Tie2 and Shp2 - Bos taurus [Reaction:R-BTA-186778] SHP2 binds to the active receptor - Bos taurus [Reaction:R-BTA-388829] SHP2 phosphatase binds CTLA-4 - Bos taurus [Reaction:R-BTA-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Bos taurus [Reaction:R-BTA-1112708] PTPN11 binds p-Y759-IL6ST - Bos taurus [Reaction:R-BTA-5654608] Activated FGFR2:p-FRS bind to PPTN11 - Bos taurus [Reaction:R-BTA-177944] Activation of SHP2 through the binding to phospho-Gab1 - Bos taurus [Reaction:R-BTA-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Bos taurus [Reaction:R-BTA-5654633] Activated FGFR3:p-FRS bind to PPTN11 - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10345025
displayName	PTPN11 [cytosol]
endCoordinate	593
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-BTA-389744] PTPN6,PTPN11 [cytosol] - Bos taurus
name	PTPN11 F1N339
negativelyRegulates	[NegativeRegulation:10345028] Negative regulation by 'PTPN11 [cytosol]'
referenceEntity	[ReferenceGeneProduct:uniprot:F1N339] UniProt:F1N339
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-162563
startCoordinate	1

Referrals

(input)	[Reaction:R-BTA-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 [Reaction:R-BTA-8865994] GAB1 binds PTPN11 [Reaction:R-BTA-205238] SHP2 interacts with p-KIT [Reaction:R-BTA-210294] Interaction of PECAM-1 and SHP-2 [Reaction:R-BTA-204873] Interaction of Tie2 and Shp2 [Reaction:R-BTA-186778] SHP2 binds to the active receptor [Reaction:R-BTA-388829] SHP2 phosphatase binds CTLA-4 [Reaction:R-BTA-8987132] IL22:p?Y251,p?Y301?IL22RA1:p?JAK1:PTPN11:IL10RB:p?TYK2 binds PTPN11 [Reaction:R-BTA-5654584] Activated FGFR1:p-FRS bind to PPTN11 [Reaction:R-BTA-1112708] PTPN11 binds p-Y759-IL6ST [Reaction:R-BTA-5654608] Activated FGFR2:p-FRS bind to PPTN11 [Reaction:R-BTA-177944] Activation of SHP2 through the binding to phospho-Gab1 [Reaction:R-BTA-5654658] Activated FGFR4:p-FRS bind to PPTN11 [Reaction:R-BTA-5654633] Activated FGFR3:p-FRS bind to PPTN11
(hasComponent)	[Complex:R-BTA-8855762] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] [Complex:R-BTA-8865998] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] [Complex:R-BTA-205267] SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] [Complex:R-BTA-210219] PECAM-1:SHP-2 complex [plasma membrane] [Complex:R-BTA-204767] pTie2 and SHP2 complex [plasma membrane] [Complex:R-BTA-186839] PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] [Complex:R-BTA-388793] pCTLA-4:Src kinases:SHP2 [plasma membrane] [Complex:R-BTA-8987108] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] [Complex:R-BTA-5654268] Activated FGFR1:p-FRS:PTPN11 [plasma membrane] [Complex:R-BTA-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] [Complex:R-BTA-5654290] Activated FGFR2:p-FRS:PTPN11 [plasma membrane] [Complex:R-BTA-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] [Complex:R-BTA-180326] EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [Complex:R-BTA-180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [Complex:R-BTA-5654337] Activated FGFR4:p-FRS:PTPN11 [plasma membrane] [Complex:R-BTA-5654310] Activated FGFR3:p-FRS:PTPN11 [plasma membrane]
(physicalEntity)	[CatalystActivity:10374396] protein tyrosine phosphatase activity of PTPN11 [cytosol]
(activeUnit)	[CatalystActivity:10347518] non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
(regulator)	[NegativeRegulation:10345028] Negative regulation by 'PTPN11 [cytosol]'
(hasMember)	[DefinedSet:R-BTA-389744] PTPN6,PTPN11 [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol]

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