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PTPN11 [cytosol]
Stable Identifier
R-BTA-162563
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
F1N339
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
RET signaling (Bos taurus)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
PECAM1 interactions (Bos taurus)
Interaction of PECAM-1 and SHP-2 (Bos taurus)
PECAM-1:SHP-2 complex [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Tie2 Signaling (Bos taurus)
Interaction of Tie2 and Shp2 (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
pTie2 and SHP2 complex [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
G6B binds PTPN6,PTPN11 (Bos taurus)
G6B:PTPN6,PTPN11 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
SYK autophosphorylates (Bos taurus)
G6B:PTPN6,PTPN11 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
p-Y7-CLEC1B dimer:PDPN binds SYK (Bos taurus)
G6B:PTPN6,PTPN11 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Platelet homeostasis (Bos taurus)
Platelet sensitization by LDL (Bos taurus)
Interaction of PECAM-1 and SHP-2 (Bos taurus)
PECAM-1:SHP-2 complex [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CTLA4 inhibitory signaling (Bos taurus)
SHP2 phosphatase binds CTLA-4 (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PD-1 signaling (Bos taurus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon alpha/beta signaling (Bos taurus)
Regulation of IFNA/IFNB signaling (Bos taurus)
Dephosphorylation of STAT1 by SHP2 (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-20 family signaling (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Bos taurus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
SHP1 and SHP2 bind the common beta chain (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Interleukin-6 family signaling (Bos taurus)
Interleukin-6 signaling (Bos taurus)
PTPN11 binds CBL (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 binds p-Y759-IL6ST (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 is phosphorylated (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Bos taurus)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
GAB1 signalosome (Bos taurus)
Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Dephosphorylation of Gab1 by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Dephosphorylation of PAG by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Sustained activation of SRC kinase by SHP2 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
FRS-mediated FGFR1 signaling (Bos taurus)
Activated FGFR1:p-FRS bind to PPTN11 (Bos taurus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Bos taurus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
FRS-mediated FGFR2 signaling (Bos taurus)
Activated FGFR2 phosphorylates PPTN11 (Bos taurus)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Activated FGFR2:p-FRS bind to PPTN11 (Bos taurus)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
FRS-mediated FGFR3 signaling (Bos taurus)
Activated FGFR3 phosphorylates PPTN11 (Bos taurus)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Activated FGFR3:p-FRS bind to PPTN11 (Bos taurus)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
FRS-mediated FGFR4 signaling (Bos taurus)
Activated FGFR4 phosphorylates PPTN11 (Bos taurus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS bind to PPTN11 (Bos taurus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Signaling by MET (Bos taurus)
MET activates PTPN11 (Bos taurus)
GAB1 binds PTPN11 (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
SHP2 binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
Phosphorylation of SHP2 by SFKs (Bos taurus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
SHP2 interacts with p-KIT (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PTPN11 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1N339
Reference Genes
BioGPS Gene:533590
ENSEMBL:ENSBTAG00000002048.5
KEGG Gene (Bos taurus):533590
Monarch:533590
NCBI Gene:533590
Reference Transcript
RefSeq:XM_002694590.5
RefSeq:XM_015467160.1
Other Identifiers
533590
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005515
GO:0005737
GO:0006470
GO:0016311
GO:0016787
GO:0016791
GO:0023052
GO:0030971
GO:0036211
GO:0050839
GO:0070374
GO:0071310
GO:0140096
Participates
as an input of
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Bos taurus)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Bos taurus)
Activated FGFR2:p-FRS bind to PPTN11 (Bos taurus)
SHP2 phosphatase binds CTLA-4 (Bos taurus)
PTPN11 binds p-Y759-IL6ST (Bos taurus)
SHP2 binds to the active receptor (Bos taurus)
GAB1 binds PTPN11 (Bos taurus)
Activated FGFR1:p-FRS bind to PPTN11 (Bos taurus)
SHP2 interacts with p-KIT (Bos taurus)
Interaction of PECAM-1 and SHP-2 (Bos taurus)
Interaction of Tie2 and Shp2 (Bos taurus)
Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)
Activated FGFR4:p-FRS bind to PPTN11 (Bos taurus)
Activated FGFR3:p-FRS bind to PPTN11 (Bos taurus)
as a component of
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PECAM-1:SHP-2 complex [plasma membrane] (Bos taurus)
pTie2 and SHP2 complex [plasma membrane] (Bos taurus)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
as a member of
PTPN6,PTPN11 [cytosol] (Bos taurus)
This entity regulates
Negatively
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
(Bos taurus)
Other forms of this molecule
PTPN11 [nucleoplasm]
phospho-p-Y542,Y580-PTPN11 [cytosol]
Inferred From
PTPN11 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_015322646.1
,
XP_002694636.2
Ensembl
ENSBTAP00000002653
,
ENSBTAT00000002653
,
ENSBTAG00000002048
VGNC
33530
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