Reactome | Interaction of PECAM-1 and SHP-2

Schema > Reaction > Entries

Interaction of PECAM-1 and SHP-2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10354207
displayName	Interaction of PECAM-1 and SHP-2
eventOf	[Pathway:R-BTA-210990] PECAM1 interactions - Bos taurus [Pathway:R-BTA-432142] Platelet sensitization by LDL - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-210294] Interaction of PECAM-1 and SHP-2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-210007] phospho-PECAM1 [plasma membrane] [EntityWithAccessionedSequence:R-BTA-162563] PTPN11 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of PECAM-1 and SHP-2
output	[Complex:R-BTA-210219] PECAM-1:SHP-2 complex [plasma membrane]
precedingEvent	[Reaction:R-BTA-210291] Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src - Bos taurus [BlackBoxEvent:R-BTA-435244] PECAM1 is phosphorylated - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-210294
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-432142] Platelet sensitization by LDL [Pathway:R-BTA-210990] PECAM1 interactions
(inferredTo)	[Reaction:R-HSA-210294] Interaction of PECAM-1 and SHP-2