Reactome | TNF-alpha inhibitors bind to soluble TNF trimer

Schema > Reaction > Entries

TNF-alpha inhibitors bind to soluble TNF trimer Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10435504
displayName	TNF-alpha inhibitors bind to soluble TNF trimer
eventOf	[Pathway:R-BTA-75893] TNF signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Homo sapiens
input	[DefinedSet:R-ALL-9714904] TNF-alpha inhibitors [extracellular region] [Complex:R-BTA-3371370] TNF-? trimer, soluble form [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	TNF-alpha inhibitors bind to soluble TNF trimer
output	[Complex:R-BTA-9714968] TNF-alpha inhibitors:TNF-alpha trimer, soluble form [extracellular region]
precedingEvent	[Reaction:R-BTA-3371385] TNF-? is cleaved by ADAM17 (TACE) - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9714924
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-75893] TNF signaling
(inferredTo)	[Reaction:R-HSA-9714924] TNF-alpha inhibitors bind to soluble TNF trimer

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