Reactome | type II FLT3-binding TKIs [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9702645] type II TKI-sensitive FLT3 mutants:type II TKIs [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9702510] FLT mutants bind type II TKIs - Homo sapiens [Reaction:R-HSA-9695831] FLT3 binds type II TKI - Homo sapiens
created	[InstanceEdit:9695787] Rothfels, Karen, 2020-07-15
dbId	9695783
displayName	type II FLT3-binding TKIs [cytosol]
hasMember	[ChemicalDrug:R-ALL-9669717] ponatinib [cytosol] [ChemicalDrug:R-ALL-9674318] quizartinib [cytosol] [ChemicalDrug:R-ALL-9657029] sorafenib [cytosol] [ChemicalDrug:R-ALL-9677649] pexidartinib [cytosol] [ChemicalDrug:R-ALL-9695994] tandutinib [cytosol] [ChemicalDrug:R-ALL-9669718] cabozantinib [cytosol] [ChemicalDrug:R-ALL-9669720] sunitinib [cytosol]
inDisease	false
maxDepth	2
modified	[InstanceEdit:9702504] Rothfels, Karen, 2020-09-30
name	type II FLT3-binding TKIs
schemaClass	DefinedSet
stId	R-ALL-9695783
updateTrackers	[UpdateTracker:9901739] Update Tracker - [DefinedSet:9695783] type II FLT3-binding TKIs [cytosol] - v75:[addHasMember, modifyName]

(updatedInstance)	[UpdateTracker:9901739] Update Tracker - [DefinedSet:9695783] type II FLT3-binding TKIs [cytosol] - v75:[addHasMember, modifyName]
(hasComponent)	[Complex:R-HSA-9702645] type II TKI-sensitive FLT3 mutants:type II TKIs [plasma membrane] [Complex:R-XTR-9695792] FLT3:FLT3-binding type II TKIs [plasma membrane] [Complex:R-CFA-9695792] FLT3:FLT3-binding type II TKIs [plasma membrane] [Complex:R-MMU-9695792] FLT3:FLT3-binding type II TKIs [plasma membrane] [Complex:R-BTA-9695792] FLT3:FLT3-binding type II TKIs [plasma membrane] [Complex:R-SSC-9695792] FLT3:FLT3-binding type II TKIs [plasma membrane] [Complex:R-HSA-9695792] FLT3:FLT3-binding type II TKIs [plasma membrane]
(input)	[Reaction:R-HSA-9702510] FLT mutants bind type II TKIs [Reaction:R-HSA-9695831] FLT3 binds type II TKI
(activeUnit)	[NegativeRegulation:9695848] Negative regulation by 'FLT3:FLT3-binding type II TKIs [plasma membrane]'