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ripretinib [cytosol]
Stable Identifier
R-ALL-9674322
Type
ChemicalDrug
Compartment
cytosol
Synonyms
DCC2618, DCC-2618
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by PDGF (Bos taurus)
PDGF dimer binds two receptors simultaneously (Bos taurus)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Bos taurus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Bos taurus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Bos taurus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Bos taurus)
Autophosphorylation of KIT (Bos taurus)
KIT:ripretinib [plasma membrane] (Bos taurus)
ripretinib [cytosol]
KIT binds ripretinib (Bos taurus)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Bos taurus)
ripretinib [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PDGF (Caenorhabditis elegans)
PDGF dimer binds two receptors simultaneously (Caenorhabditis elegans)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Caenorhabditis elegans)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Caenorhabditis elegans)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Caenorhabditis elegans)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Caenorhabditis elegans)
KIT binds ripretinib (Caenorhabditis elegans)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Caenorhabditis elegans)
ripretinib [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PDGF (Canis familiaris)
PDGF dimer binds two receptors simultaneously (Canis familiaris)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Canis familiaris)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Canis familiaris)
Autophosphorylation of KIT (Canis familiaris)
KIT:ripretinib [plasma membrane] (Canis familiaris)
ripretinib [cytosol]
KIT binds ripretinib (Canis familiaris)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Canis familiaris)
ripretinib [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by PDGF (Danio rerio)
PDGF dimer binds two receptors simultaneously (Danio rerio)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Danio rerio)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Danio rerio)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Danio rerio)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Danio rerio)
Autophosphorylation of KIT (Danio rerio)
KIT:ripretinib [plasma membrane] (Danio rerio)
ripretinib [cytosol]
KIT binds ripretinib (Danio rerio)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Danio rerio)
ripretinib [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by PDGF (Drosophila melanogaster)
PDGF dimer binds two receptors simultaneously (Drosophila melanogaster)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Drosophila melanogaster)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Drosophila melanogaster)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Drosophila melanogaster)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Drosophila melanogaster)
KIT binds ripretinib (Drosophila melanogaster)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Drosophila melanogaster)
ripretinib [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by PDGF (Gallus gallus)
PDGF dimer binds two receptors simultaneously (Gallus gallus)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Gallus gallus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Gallus gallus)
Autophosphorylation of KIT (Gallus gallus)
KIT:ripretinib [plasma membrane] (Gallus gallus)
ripretinib [cytosol]
KIT binds ripretinib (Gallus gallus)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Gallus gallus)
ripretinib [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by KIT in disease (Homo sapiens)
KIT mutants bind TKIs (Homo sapiens)
KIT mutants bind ripretinib (Homo sapiens)
ripretinib [cytosol]
ripretinib-sensitive KIT:ripretinib [plasma membrane] (Homo sapiens)
ripretinib [cytosol]
Signaling by PDGFR in disease (Homo sapiens)
PDGFR mutants bind TKIs (Homo sapiens)
PDGFR mutants bind type II TKIs (Homo sapiens)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
type II sensitive PDGFR mutants:type II TKIs [plasma membrane] (Homo sapiens)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
PDGF dimer binds two receptors simultaneously (Homo sapiens)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Homo sapiens)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Homo sapiens)
Autophosphorylation of KIT (Homo sapiens)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Homo sapiens)
ripretinib [cytosol]
KIT binds ripretinib (Homo sapiens)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Homo sapiens)
ripretinib [cytosol]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by PDGF (Mus musculus)
PDGF dimer binds two receptors simultaneously (Mus musculus)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Mus musculus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Mus musculus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Mus musculus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Mus musculus)
Autophosphorylation of KIT (Mus musculus)
KIT:ripretinib [plasma membrane] (Mus musculus)
ripretinib [cytosol]
KIT binds ripretinib (Mus musculus)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Mus musculus)
ripretinib [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
PDGF dimer binds two receptors simultaneously (Rattus norvegicus)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Rattus norvegicus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Rattus norvegicus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Rattus norvegicus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Rattus norvegicus)
Autophosphorylation of KIT (Rattus norvegicus)
KIT:ripretinib [plasma membrane] (Rattus norvegicus)
ripretinib [cytosol]
KIT binds ripretinib (Rattus norvegicus)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Rattus norvegicus)
ripretinib [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by PDGF (Sus scrofa)
PDGF dimer binds two receptors simultaneously (Sus scrofa)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Sus scrofa)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Sus scrofa)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Sus scrofa)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Sus scrofa)
Autophosphorylation of KIT (Sus scrofa)
KIT:ripretinib [plasma membrane] (Sus scrofa)
ripretinib [cytosol]
KIT binds ripretinib (Sus scrofa)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Sus scrofa)
ripretinib [cytosol]
Signal Transduction (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by PDGF (Xenopus tropicalis)
PDGF dimer binds two receptors simultaneously (Xenopus tropicalis)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Xenopus tropicalis)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFRs bind type II TKI (Xenopus tropicalis)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Xenopus tropicalis)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
ripretinib [cytosol]
Signaling by SCF-KIT (Xenopus tropicalis)
Autophosphorylation of KIT (Xenopus tropicalis)
KIT:ripretinib [plasma membrane] (Xenopus tropicalis)
ripretinib [cytosol]
KIT binds ripretinib (Xenopus tropicalis)
ripretinib [cytosol]
KIT:ripretinib [plasma membrane] (Xenopus tropicalis)
ripretinib [cytosol]
External Reference Information
External Reference
ripretinib [Guide to Pharmacology:9175]
Participates
as a component of
ripretinib-sensitive KIT:ripretinib [plasma membrane] (Homo sapiens)
KIT:ripretinib [plasma membrane] (Xenopus tropicalis)
KIT:ripretinib [plasma membrane] (Rattus norvegicus)
KIT:ripretinib [plasma membrane] (Caenorhabditis elegans)
KIT:ripretinib [plasma membrane] (Canis familiaris)
KIT:ripretinib [plasma membrane] (Sus scrofa)
KIT:ripretinib [plasma membrane] (Drosophila melanogaster)
KIT:ripretinib [plasma membrane] (Gallus gallus)
KIT:ripretinib [plasma membrane] (Danio rerio)
KIT:ripretinib [plasma membrane] (Mus musculus)
KIT:ripretinib [plasma membrane] (Homo sapiens)
KIT:ripretinib [plasma membrane] (Bos taurus)
as an input of
KIT mutants bind ripretinib (Homo sapiens)
KIT binds ripretinib (Caenorhabditis elegans)
KIT binds ripretinib (Drosophila melanogaster)
KIT binds ripretinib (Gallus gallus)
KIT binds ripretinib (Xenopus tropicalis)
KIT binds ripretinib (Sus scrofa)
KIT binds ripretinib (Bos taurus)
KIT binds ripretinib (Canis familiaris)
KIT binds ripretinib (Rattus norvegicus)
KIT binds ripretinib (Mus musculus)
KIT binds ripretinib (Homo sapiens)
KIT binds ripretinib (Danio rerio)
as a member of
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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