Reactome | PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate

Schema > Reaction > Entries

PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate Show undefined attributes

catalystActivity	[CatalystActivity:177980] fructose-2,6-bisphosphate 2-phosphatase activity of p-PFKFB1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667588] RHEA:17290 [DatabaseIdentifier:9933530] RHEA:17290
dbId	70262
deleted	[Deleted:617380] Deletion of instances: 71809, 71807, 71803 [Deleted:372876] Deletion of instance: 71805
displayName	PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate
eventOf	[Pathway:R-HSA-9634600] Regulation of glycolysis by fructose 2,6-bisphosphate metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24887] negative regulation of glycolytic process
input	[SimpleEntity:R-ALL-30533] D-Fructose 2,6-bisphosphate [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70163] 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
orthologousEvent	[Reaction:R-DRE-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Danio rerio [Reaction:R-SCE-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Saccharomyces cerevisiae [Reaction:R-SPO-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Schizosaccharomyces pombe [Reaction:R-DDI-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Dictyostelium discoideum [Reaction:R-CEL-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Caenorhabditis elegans [Reaction:R-DME-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Drosophila melanogaster [Reaction:R-GGA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Gallus gallus [Reaction:R-XTR-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Xenopus tropicalis [Reaction:R-SSC-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Sus scrofa [Reaction:R-BTA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Bos taurus [Reaction:R-CFA-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Canis familiaris [Reaction:R-RNO-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Rattus norvegicus [Reaction:R-MMU-70262] PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate - Mus musculus
output	[SimpleEntity:R-ALL-29512] Fru(6)P [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70262
summation	[Summation:178796] The fructose 2,6-bisphosphatase activity of cytosolic phosph...
updateTrackers	[UpdateTracker:9791767] Update Tracker - [Reaction:70262] Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate - v26:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791767] Update Tracker - [Reaction:70262] Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate - v26:[modifyText]
(replacementInstances)	[Deleted:617380] Deletion of instances: 71809, 71807, 71803 [Deleted:372876] Deletion of instance: 71805
(hasEvent)	[Pathway:R-HSA-9634600] Regulation of glycolysis by fructose 2,6-bisphosphate metabolism