Reactome | HA [extracellular region]

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HA [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-RNO-2160889] HA:HAR:HYAL2 [plasma membrane] - Rattus norvegicus [Complex:R-GGA-2318621] Aggrecan:HA:HAPLN1 [extracellular region] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-2160915] Receptor-mediated uptake of HA - Gallus gallus [Reaction:R-DRE-2160915] Receptor-mediated uptake of HA - Danio rerio [Reaction:R-SSC-2160915] Receptor-mediated uptake of HA - Sus scrofa [Reaction:R-BTA-2160915] Receptor-mediated uptake of HA - Bos taurus [Reaction:R-CFA-2160915] Receptor-mediated uptake of HA - Canis familiaris [Reaction:R-RNO-2160915] Receptor-mediated uptake of HA - Rattus norvegicus [Reaction:R-MMU-2160915] Receptor-mediated uptake of HA - Mus musculus [Reaction:R-HSA-2160915] Receptor-mediated uptake of HA - Homo sapiens [BlackBoxEvent:R-CEL-9941055] SPAM1 randomly cleaves HA - Caenorhabditis elegans [BlackBoxEvent:R-XTR-9941055] SPAM1 randomly cleaves HA - Xenopus tropicalis [BlackBoxEvent:R-DRE-9941055] SPAM1 randomly cleaves HA - Danio rerio [Reaction:R-DDI-5693356] CEMIP hydrolyzes HA - Dictyostelium discoideum [BlackBoxEvent:R-GGA-9941055] SPAM1 randomly cleaves HA - Gallus gallus [Reaction:R-GGA-5693356] CEMIP hydrolyzes HA - Gallus gallus [BlackBoxEvent:R-HSA-9941055] SPAM1 randomly cleaves HA - Homo sapiens [Reaction:R-HSA-5693356] CEMIP hydrolyzes HA - Homo sapiens [Reaction:R-MMU-5693356] CEMIP hydrolyzes HA - Mus musculus [BlackBoxEvent:R-MMU-9941055] SPAM1 randomly cleaves HA - Mus musculus [Reaction:R-RNO-5693356] CEMIP hydrolyzes HA - Rattus norvegicus [BlackBoxEvent:R-RNO-9941055] SPAM1 randomly cleaves HA - Rattus norvegicus [Reaction:R-CFA-5693356] CEMIP hydrolyzes HA - Canis familiaris [BlackBoxEvent:R-CFA-9941055] SPAM1 randomly cleaves HA - Canis familiaris [Reaction:R-BTA-5693356] CEMIP hydrolyzes HA - Bos taurus [BlackBoxEvent:R-BTA-9941055] SPAM1 randomly cleaves HA - Bos taurus [Reaction:R-SSC-5693356] CEMIP hydrolyzes HA - Sus scrofa [BlackBoxEvent:R-SSC-9941055] SPAM1 randomly cleaves HA - Sus scrofa [Reaction:R-GGA-2318623] Aggrecan binds Hyaluronan and HAPLN1 - Gallus gallus [Reaction:R-DRE-2318623] Aggrecan binds Hyaluronan and HAPLN1 - Danio rerio [Reaction:R-SSC-2318623] Aggrecan binds Hyaluronan and HAPLN1 - Sus scrofa [Reaction:R-BTA-2318623] Aggrecan binds Hyaluronan and HAPLN1 - Bos taurus [Reaction:R-CFA-2318623] Aggrecan binds Hyaluronan and HAPLN1 - Canis familiaris [Reaction:R-RNO-2318623] Aggrecan binds Hyaluronan and HAPLN1 - Rattus norvegicus [Reaction:R-MMU-2318623] Aggrecan binds Hyaluronan and HAPLN1 - Mus musculus [Reaction:R-HSA-2318623] Aggrecan binds Hyaluronan and HAPLN1 - Homo sapiens [BlackBoxEvent:R-HSA-9941244] ROS/RNS degrade HA - Homo sapiens
created	[InstanceEdit:2160887] Jassal, B, 2012-03-05
crossReference	[DatabaseIdentifier:9954863] ChEBI:132153
dbId	2160848
displayName	HA [extracellular region]
inDisease	false
maxDepth	2
modified	[InstanceEdit:9954864] D'Eustachio, Peter, 2025-06-09
name	HA HA polymer Hyaluronan Hyaluronic acid
producedByEvent	[BlackBoxEvent:R-CEL-9941055] SPAM1 randomly cleaves HA - Caenorhabditis elegans [BlackBoxEvent:R-XTR-9941055] SPAM1 randomly cleaves HA - Xenopus tropicalis [BlackBoxEvent:R-DRE-9941055] SPAM1 randomly cleaves HA - Danio rerio [Reaction:R-DDI-5693356] CEMIP hydrolyzes HA - Dictyostelium discoideum [BlackBoxEvent:R-GGA-9941055] SPAM1 randomly cleaves HA - Gallus gallus [Reaction:R-GGA-5693356] CEMIP hydrolyzes HA - Gallus gallus [BlackBoxEvent:R-HSA-9941055] SPAM1 randomly cleaves HA - Homo sapiens [Reaction:R-HSA-5693356] CEMIP hydrolyzes HA - Homo sapiens [Reaction:R-MMU-5693356] CEMIP hydrolyzes HA - Mus musculus [BlackBoxEvent:R-MMU-9941055] SPAM1 randomly cleaves HA - Mus musculus [Reaction:R-RNO-5693356] CEMIP hydrolyzes HA - Rattus norvegicus [BlackBoxEvent:R-RNO-9941055] SPAM1 randomly cleaves HA - Rattus norvegicus [Reaction:R-CFA-5693356] CEMIP hydrolyzes HA - Canis familiaris [BlackBoxEvent:R-CFA-9941055] SPAM1 randomly cleaves HA - Canis familiaris [Reaction:R-BTA-5693356] CEMIP hydrolyzes HA - Bos taurus [BlackBoxEvent:R-BTA-9941055] SPAM1 randomly cleaves HA - Bos taurus [Reaction:R-SSC-5693356] CEMIP hydrolyzes HA - Sus scrofa [BlackBoxEvent:R-SSC-9941055] SPAM1 randomly cleaves HA - Sus scrofa [BlackBoxEvent:R-HSA-9941244] ROS/RNS degrade HA - Homo sapiens [Reaction:R-BTA-2142859] Growing HA is extruded from the cell by ABCC5 - Bos taurus [Reaction:R-HSA-2142859] Growing HA is extruded from the cell by ABCC5 - Homo sapiens [Reaction:R-MMU-2142859] Growing HA is extruded from the cell by ABCC5 - Mus musculus [Reaction:R-RNO-2142859] Growing HA is extruded from the cell by ABCC5 - Rattus norvegicus [Reaction:R-CFA-2142859] Growing HA is extruded from the cell by ABCC5 - Canis familiaris [Reaction:R-SSC-2142859] Growing HA is extruded from the cell by ABCC5 - Sus scrofa [Reaction:R-DRE-2142859] Growing HA is extruded from the cell by ABCC5 - Danio rerio [Reaction:R-XTR-2142859] Growing HA is extruded from the cell by ABCC5 - Xenopus tropicalis [Reaction:R-GGA-2142859] Growing HA is extruded from the cell by ABCC5 - Gallus gallus [Reaction:R-CEL-2142859] Growing HA is extruded from the cell by ABCC5 - Caenorhabditis elegans [Reaction:R-DDI-2142859] Growing HA is extruded from the cell by ABCC5 - Dictyostelium discoideum [Polymerisation:R-BTA-2160851] HAS1,2,3 mediate the polymerization and export of HA - Bos taurus [Polymerisation:R-HSA-2160851] HAS1,2,3 mediate the polymerization and export of HA - Homo sapiens [Polymerisation:R-MMU-2160851] HAS1,2,3 mediate the polymerization and export of HA - Mus musculus [Polymerisation:R-RNO-2160851] HAS1,2,3 mediate the polymerization and export of HA - Rattus norvegicus [Polymerisation:R-CFA-2160851] HAS1,2,3 mediate the polymerization and export of HA - Canis familiaris [Polymerisation:R-SSC-2160851] HAS1,2,3 mediate the polymerization and export of HA - Sus scrofa [Polymerisation:R-XTR-2160851] HAS1,2,3 mediate the polymerization and export of HA - Xenopus tropicalis [Polymerisation:R-GGA-2160851] HAS1,2,3 mediate the polymerization and export of HA - Gallus gallus
repeatedUnit	[SimpleEntity:R-ALL-5693343] GlcA-b1,3-GlcNAc [extracellular region]
schemaClass	Polymer
stId	R-ALL-2160848
updateTrackers	[UpdateTracker:9897446] Update Tracker - [Polymer:2160848] HA [extracellular region] - v62:[add_removeRepeatedUnit]

Referrals

(hasComponent)	[Complex:R-GGA-2318621] Aggrecan:HA:HAPLN1 [extracellular region] [Complex:R-BTA-2318621] Aggrecan:HA:HAPLN1 [extracellular region] [Complex:R-RNO-2318621] Aggrecan:HA:HAPLN1 [extracellular region] [Complex:R-SSC-2318621] Aggrecan:HA:HAPLN1 [extracellular region] [Complex:R-MMU-2318621] Aggrecan:HA:HAPLN1 [extracellular region] [Complex:R-CFA-2318621] Aggrecan:HA:HAPLN1 [extracellular region] [Complex:R-DRE-2318621] Aggrecan:HA:HAPLN1 [extracellular region] [Complex:R-HSA-2318621] Aggrecan:HA:HAPLN1 [extracellular region] [Complex:R-RNO-2160889] HA:HAR:HYAL2 [plasma membrane] [Complex:R-CFA-2160889] HA:HAR:HYAL2 [plasma membrane] [Complex:R-GGA-2160889] HA:HAR:HYAL2 [plasma membrane] [Complex:R-DRE-2160889] HA:HAR:HYAL2 [plasma membrane] [Complex:R-MMU-2160889] HA:HAR:HYAL2 [plasma membrane] [Complex:R-BTA-2160889] HA:HAR:HYAL2 [plasma membrane] [Complex:R-SSC-2160889] HA:HAR:HYAL2 [plasma membrane] [Complex:R-HSA-2160889] HA:HAR:HYAL2 [plasma membrane]
(input)	[Reaction:R-GGA-2318623] Aggrecan binds Hyaluronan and HAPLN1 [Reaction:R-DRE-2318623] Aggrecan binds Hyaluronan and HAPLN1 [Reaction:R-SSC-2318623] Aggrecan binds Hyaluronan and HAPLN1 [Reaction:R-BTA-2318623] Aggrecan binds Hyaluronan and HAPLN1 [Reaction:R-CFA-2318623] Aggrecan binds Hyaluronan and HAPLN1 [Reaction:R-RNO-2318623] Aggrecan binds Hyaluronan and HAPLN1 [Reaction:R-MMU-2318623] Aggrecan binds Hyaluronan and HAPLN1 [Reaction:R-HSA-2318623] Aggrecan binds Hyaluronan and HAPLN1 [Reaction:R-GGA-2160915] Receptor-mediated uptake of HA [Reaction:R-DRE-2160915] Receptor-mediated uptake of HA [Reaction:R-SSC-2160915] Receptor-mediated uptake of HA [Reaction:R-BTA-2160915] Receptor-mediated uptake of HA [Reaction:R-CFA-2160915] Receptor-mediated uptake of HA [Reaction:R-RNO-2160915] Receptor-mediated uptake of HA [Reaction:R-MMU-2160915] Receptor-mediated uptake of HA [Reaction:R-HSA-2160915] Receptor-mediated uptake of HA [BlackBoxEvent:R-CEL-9941055] SPAM1 randomly cleaves HA [BlackBoxEvent:R-XTR-9941055] SPAM1 randomly cleaves HA [BlackBoxEvent:R-DRE-9941055] SPAM1 randomly cleaves HA [Reaction:R-DDI-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-GGA-9941055] SPAM1 randomly cleaves HA [Reaction:R-GGA-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-HSA-9941055] SPAM1 randomly cleaves HA [Reaction:R-HSA-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-HSA-9941244] ROS/RNS degrade HA [Reaction:R-MMU-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-MMU-9941055] SPAM1 randomly cleaves HA [Reaction:R-RNO-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-RNO-9941055] SPAM1 randomly cleaves HA [Reaction:R-CFA-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-CFA-9941055] SPAM1 randomly cleaves HA [Reaction:R-BTA-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-BTA-9941055] SPAM1 randomly cleaves HA [Reaction:R-SSC-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-SSC-9941055] SPAM1 randomly cleaves HA
(output)	[BlackBoxEvent:R-CEL-9941055] SPAM1 randomly cleaves HA [BlackBoxEvent:R-XTR-9941055] SPAM1 randomly cleaves HA [BlackBoxEvent:R-DRE-9941055] SPAM1 randomly cleaves HA [Reaction:R-DDI-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-GGA-9941055] SPAM1 randomly cleaves HA [Reaction:R-GGA-5693356] CEMIP hydrolyzes HA [Polymerisation:R-BTA-2160851] HAS1,2,3 mediate the polymerization and export of HA [Polymerisation:R-HSA-2160851] HAS1,2,3 mediate the polymerization and export of HA [Polymerisation:R-MMU-2160851] HAS1,2,3 mediate the polymerization and export of HA [Polymerisation:R-RNO-2160851] HAS1,2,3 mediate the polymerization and export of HA [Polymerisation:R-CFA-2160851] HAS1,2,3 mediate the polymerization and export of HA [Polymerisation:R-SSC-2160851] HAS1,2,3 mediate the polymerization and export of HA [Polymerisation:R-XTR-2160851] HAS1,2,3 mediate the polymerization and export of HA [Polymerisation:R-GGA-2160851] HAS1,2,3 mediate the polymerization and export of HA [Reaction:R-BTA-2142859] Growing HA is extruded from the cell by ABCC5 [Reaction:R-HSA-2142859] Growing HA is extruded from the cell by ABCC5 [Reaction:R-MMU-2142859] Growing HA is extruded from the cell by ABCC5 [Reaction:R-RNO-2142859] Growing HA is extruded from the cell by ABCC5 [Reaction:R-CFA-2142859] Growing HA is extruded from the cell by ABCC5 [Reaction:R-SSC-2142859] Growing HA is extruded from the cell by ABCC5 [Reaction:R-DRE-2142859] Growing HA is extruded from the cell by ABCC5 [Reaction:R-XTR-2142859] Growing HA is extruded from the cell by ABCC5 [Reaction:R-GGA-2142859] Growing HA is extruded from the cell by ABCC5 [Reaction:R-CEL-2142859] Growing HA is extruded from the cell by ABCC5 [Reaction:R-DDI-2142859] Growing HA is extruded from the cell by ABCC5 [BlackBoxEvent:R-HSA-9941055] SPAM1 randomly cleaves HA [Reaction:R-HSA-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-HSA-9941244] ROS/RNS degrade HA [Reaction:R-MMU-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-MMU-9941055] SPAM1 randomly cleaves HA [Reaction:R-RNO-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-RNO-9941055] SPAM1 randomly cleaves HA [Reaction:R-CFA-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-CFA-9941055] SPAM1 randomly cleaves HA [Reaction:R-BTA-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-BTA-9941055] SPAM1 randomly cleaves HA [Reaction:R-SSC-5693356] CEMIP hydrolyzes HA [BlackBoxEvent:R-SSC-9941055] SPAM1 randomly cleaves HA
(updatedInstance)	[UpdateTracker:9897446] Update Tracker - [Polymer:2160848] HA [extracellular region] - v62:[add_removeRepeatedUnit]

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