Reactome | HAS1,2,3 mediate the polymerization and export of HA

Schema > Polymerisation > Entries

HAS1,2,3 mediate the polymerization and export of HA Show undefined attributes

catalystActivity	[CatalystActivity:10042483] hyaluronan synthase activity of HAS1,2,3:Mg2+ [plasma membrane]
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10042485
displayName	HAS1,2,3 mediate the polymerization and export of HA
eventOf	[Pathway:R-MMU-2142845] Hyaluronan metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2160915] Receptor-mediated uptake of HA - Mus musculus [BlackBoxEvent:R-MMU-9941055] SPAM1 randomly cleaves HA - Mus musculus [Reaction:R-MMU-5693356] CEMIP hydrolyzes HA - Mus musculus [Reaction:R-MMU-2142859] Growing HA is extruded from the cell by ABCC5 - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:21628] hyaluronan biosynthetic process
inferredFrom	[Polymerisation:R-HSA-2160851] HAS1,2,3 mediate the polymerization and export of HA - Homo sapiens
input	[SimpleEntity:R-ALL-158601] UDP-GlcA [cytosol] [SimpleEntity:R-ALL-162756] UDP-GlcNAc [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HAS1,2,3 mediate the polymerization and export of HA
output	2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [Polymer:R-ALL-2160848] HA [extracellular region] 2 × [SimpleEntity:R-ALL-110096] UDP [cytosol]
precedingEvent	[Reaction:R-MMU-446204] GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine - Mus musculus [Reaction:R-MMU-173597] UDP-glucose is oxidised to UDP-glucuronate - Mus musculus
regulatedBy	[PositiveRegulation:10042486] Positive regulation by 'UTP [extracellular region]' [PositiveRegulation:10042487] Positive regulation by 'UDP-Glc [extracellular region]'
releaseDate	2026-03-25
schemaClass	Polymerisation
species	[Species:48892] Mus musculus
stId	R-MMU-2160851
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2142845] Hyaluronan metabolism
(precedingEvent)	[Reaction:R-MMU-2160915] Receptor-mediated uptake of HA [BlackBoxEvent:R-MMU-9941055] SPAM1 randomly cleaves HA [Reaction:R-MMU-5693356] CEMIP hydrolyzes HA [Reaction:R-MMU-2142859] Growing HA is extruded from the cell by ABCC5
(inferredTo)	[Polymerisation:R-HSA-2160851] HAS1,2,3 mediate the polymerization and export of HA