Reactome | Aggrecan binds Hyaluronan and HAPLN1

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10781292
displayName	Aggrecan binds Hyaluronan and HAPLN1
eventOf	[Pathway:R-GGA-3000178] ECM proteoglycans - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2318623] Aggrecan binds Hyaluronan and HAPLN1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-2318645] ACAN [extracellular region] [Polymer:R-ALL-2160848] HA [extracellular region] [EntityWithAccessionedSequence:R-GGA-2299700] HAPLN1 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Aggrecan binds Hyaluronan and HAPLN1
output	[Complex:R-GGA-2318621] Aggrecan:HA:HAPLN1 [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2318623
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-3000178] ECM proteoglycans
(inferredTo)	[Reaction:R-HSA-2318623] Aggrecan binds Hyaluronan and HAPLN1

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