Reactome | Negative regulation by 'ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]'

Schema > NegativeRegulation > Entries

activeUnit	[Complex:R-HSA-9759097] SQSTM1 oligomer [cytosol] - Homo sapiens
created	[InstanceEdit:9759127] Rothfels, Karen, 2021-11-29
dbId	9759128
displayName	Negative regulation by 'ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]'
modified	[InstanceEdit:9766673] Rothfels, Karen, 2022-02-23
regulatedEntity	[Reaction:R-HSA-8932327] NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 - Homo sapiens
regulator	[Complex:R-HSA-9766542] ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
schemaClass	NegativeRegulation

(regulation)	[RegulationReference:9759126] Negative regulation by 'ub-K420 p-S349 SQSTM1 oligomer:KEAP1:CUL3:RBX1 [cytosol]' p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
(regulatedBy)	[Reaction:R-HSA-8932327] NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1

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